Fig. 8

Effects of the intraperitoneal administration of thymol for 15 days on 6- OHDA-induced rotarod performance impairment. The animals were tested in the rotarod at week 2 in two settings, 5–45 rpm increase over 200 s (a, b) and 5–20 rpm increase over 20 s (c, d). This motor competency task was impaired in the 6-OHDA-lesioned animals. The thymol treatment improved the animals’ performance after the lesion. e In the open-field behavior, the overall distance covered was reduced by the 6-OHDA lesion and normalized by thymol. The values are presented by means ± SD for six rats in each group. *p < 0.05, **p < 0.01 and ***p < 0.001 versus the untreated control group; # p < 0.05 and ### p < 0.001 versus the 6- OHDA-treated groups