Fig. 1
From: In vitro evaluation of the inhibition potential of echinacoside on human cytochrome P450 isozymes
Effects of ECH on metabolite formation are shown as indexes of CYPs activity in HLM (CYP1A2, CYP2E1, CYP2C19, CYP3A4, CYP2A6, CYP2C8, CYP2C9, and CYP2D6). ECH: incubation with 100 μM ECH. Positive inhibitor: incubation with specific inhibitors, phenacetin (for CYP1A2), chlorzoxazone (for CYP2E1), S-mephenytoin (for CYP2C19), testosterone (for CYP3A4), coumarin (for CYP2A6), paclitaxel (for CYP2C8), diclofenac (for CYP2C9), dextromethorphan (for CYP2D6). Blank HLMs was incubated as Control. ***P < 0.001 vs Control activity. ECH: echinacoside