Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice

Table 3 Effects of crude extract and solvent fractions of the leaves of B. abyssinica on intestinal motility

Types of treatment	The total length of the intestine (cm)	Length of intestine marked with charcoal (cm)	PI (%)	Inhibition of motility (%)
NEC	57.58 ± 0.87	33.75 ± 1.57	58.76 ± 3.26	–––––––-
Atropine 5 mg/kg	58.50 ± 0.80	18.75 ± 1.57	32.03 ± 2.62	45.49
Crude extract (mg/kg)
100	59.83 ± 1.72	27.25 ± 1.67^b1	45.83 ± 3.48^b1	22.00
200	57.5 ± 0.61	25.17 ± 1.81^a1	43.92 ± 3.54^a1	25.26
400	57.73 ± 0.95	23.33 ± 1.76^a2	40.48 ± 3.17^a2	31.11
AF (mg/kg)
100	55.92 ± 0.72	25.67 ± 1.08^a2b1	45.93 ± 1.97^a1b2	21.83
200	56.42 ± 1.00	23.33 ± 1.26^a3	41.43 ± 2.39^a2	29.49
400	57.00 ± 0.76	22.42 ± 1.34^a3	39.47 ± 2.82^a3	32.83
CF (mg/kg)
100	57.75 ± 1.24	31.33 ± 1.42 ^b3e2	54.24 ± 2.06^b3e2	7.69
200	57.92 ± 1.36	28.67 ± 2.00^b2	49.30 ± 2.67^b3	16.10
400	57.67 ± 2.46	21.33 ± 1.60^a3c2	36.89 ± 1.89^a3c2	37.22
NHF (mg/kg)
100	57.83 ± 1.07	31.83 ± 1.49 ^b3e2	55.16 ± 2.86 ^b3e2	6.13
200	57.17 ± 1.12	30.08 ± 1.65^b3e1	52.88 ± 3.32^b2e1	10.01
400	58.08 ± 0.98	21.75 ± 1.53^a3c2d1	37.67 ± 3.30^a2c2d1	35.89

Results are expressed as mean ± SEM (n = 6); statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. ^acompared to negative control, ^bcompared to atropine, ^ccompared to 100 mg/kg, ^dcompared to 200 mg/kg, ^ecompared to 400 mg/kg. ¹p < 0.05, ²p < 0.01, ^3p < 0.001.NC Negative control

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