An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Table 4 Analgesic effects of synthetic test compounds in thermal-induced nociception model

Groups	Treatments	Dose mg/kg	Minutes after treatment
Groups	Treatments	Dose mg/kg	0	15	30	60
Response in sec (Mean ± SEM)
1	DMSO	10 ml/kg	3.238 ± 0.125	3.45 ± 0.056	3.53 ± 0.076	3.367 ± 0.145
2	Ibuprofen	100	5.1 ± 0.068**	5.667 ± 0.136**	8.43 ± 0.123***	13.45 ± 0.287***
3	3	25	4.0 ± 0.082*	4.6 ± 0.089*	5.58 ± 0.119**	9.33 ± 0.133**
4		50	5.417 ± 0.111**	6.28 ± 0.095 **	8.71 ± 0.207***	13.517 ± 0.250***
5		75	5.8 ± 0.1***	8.15 ± 0.177 ***	10.81 ± 0.119***	18.267 ± 0.217***
6	5	50	4.583 ± 0.149*	5.36 ± 0.133**	6.317 ± 0.079**	10.817 ± 0.199**
7		75	5.567 ± 0.138**	7.7 ± 0.142***	9.583 ± 0.087***	13.9 ± 0.146***
8		100	6.13 ± 0.165***	8.121 ± 0.185***	10.117 ± 0.149***	16.48 ± 0.288***

Analgesic effect of compounds, Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, (n = 6)
^*Significant inhibition of nociceptive response (P < 0.05)
^**very significant inhibition of nociceptive response (P < 0.01)
^***Highly significant inhibition of nociceptive response (P < 0.001)

ISSN: 2662-7671