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Table 4 Analgesic effects of synthetic test compounds in thermal-induced nociception model

From: An in vivo evaluation of anti-inflammatory, analgesic and anti-pyretic activities of newly synthesized 1, 2, 4 Triazole derivatives

Groups Treatments Dose mg/kg Minutes after treatment
0 15 30 60
Response in sec (Mean ± SEM)
1 DMSO 10 ml/kg 3.238 ± 0.125 3.45 ± 0.056 3.53 ± 0.076 3.367 ± 0.145
2 Ibuprofen 100 5.1 ± 0.068** 5.667 ± 0.136** 8.43 ± 0.123*** 13.45 ± 0.287***
3 3 25 4.0 ± 0.082* 4.6 ± 0.089* 5.58 ± 0.119** 9.33 ± 0.133**
4 50 5.417 ± 0.111** 6.28 ± 0.095
**
8.71 ± 0.207*** 13.517 ± 0.250***
5 75 5.8 ± 0.1*** 8.15 ± 0.177
***
10.81 ± 0.119*** 18.267 ± 0.217***
6 5 50 4.583 ± 0.149* 5.36 ± 0.133** 6.317 ± 0.079** 10.817 ± 0.199**
7 75 5.567 ± 0.138** 7.7 ± 0.142*** 9.583 ± 0.087*** 13.9 ± 0.146***
8 100 6.13 ± 0.165*** 8.121 ± 0.185*** 10.117 ± 0.149*** 16.48 ± 0.288***
  1. Analgesic effect of compounds, Data expressed as mean ± SEM, one-way ANOVA followed by post Dunnett’s test, (n = 6)
  2. *Significant inhibition of nociceptive response (P < 0.05)
  3. **very significant inhibition of nociceptive response (P < 0.01)
  4. ***Highly significant inhibition of nociceptive response (P < 0.001)