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Table 4 Biochemical profile of rats treated with A. vera for 28 days

From: Acute and sub-acute oral toxicity of aqueous whole leaf and green rind extracts of Aloe vera in Wistar rats

Biochemical parameters

Control group

A. vera whole leaf extract dose levels in mg/kg

A. vera green rind extract dose levels in mg/kg

200

400

800

200

400

800

Combined male and female

 CREAT (mg/dl)

0.57 ± 0.03

0.48 ± 0.04

0.42 ± 0.06

0.49 ± 0.09

0.86 ± 0.07**

0.85 ± 0.06**

0.83 ± 0.06**

 Urea (mg/dl)

44.90 ± 3.16

48.42 ± 2.70

48.38 ± 2.80

44.32 ± 3.20

50.15 ± 4.63

45.40 ± 3.22

38.57 ± 3.58

 ALT (U/L)

69.40 ± 8.19

65.83 ± 2.36

60.17 ± 5.08

70.50 ± 4.72

104.00 ± 12.86

87.50 ± 13.02

102.50 ± 11.18

 AST (U/L)

147.40 ± 13.08

138.50 ± 10.82

139.70 ± 9.53

125.70 ± 2.86

136.00 ± 4.41

128.00 ± 10.13

155.80 ± 15.03

 Tot Chol (mg/dl)

50.40 ± 4.08

54.17 ± 5.65

41.67 ± 3.45

52.50 ± 5.93

107.50 ± 19.67

121.70 ± 14.62**

143.0 ± 12.40**

 Na + (mmol/l)

147.80 ± 1.04

147.70 ± 0.45

147.20 ± 0.74

147.60 ± 0.61

146.60 ± 0.32

145.90 ± 0.55

145.60 ± 0.39

 K+ (mmol/l)

6.98 ± 0.13

6.06 ± 0.16

6.10 ± 0.48

5.97 ± 0.13

6.06 ± 0.19

6.12 ± 0.37

6.37 ± 0.36

 Cl- (mmol/l)

111.40 ± 2.81

154.60 ± 4.29**

145.30 ± 5.58**

148.20 ± 8.18**

103.80 ± 0.61**

104.80 ± 0.39**

105.30 ± 0.73**

Females

 CREAT (mg/dL)

0.58 ± 0.02

0.43 ± 0.03

0.41 ± 0.05

0.67 ± 0.06

0.95 ± 0.09*

0.93 ± 0.06*

0.90 ± 0.02*

 Urea (mg/dL)

49.05 ± 3.55

50.60 ± 5.36

48.07 ± 2.35

41.73 ± 1.61

57.90 ± 6.21

48.23 ± 6.15

43.87 ± 1.72

 ALT (U/L)

53.50 ± 10.50

65.33 ± 2.40

59.00 ± 4.93

71.67 ± 6.64

85.33 ± 9.96

59.33 ± 5.49

101.00 ± 23.18

 AST (U/L)

155.00 ± 9.00

148.7 ± 15.94

140.70 ± 3.84

129.30 ± 3.18

134.00 ± 7.21

121.30 ± 20.46

172.30 ± 7.22

 Tot Chol (mg/dL)

49.05 ± 1.50

64.33 ± 4.49

46.67 ± 5.81

60.67 ± 4.67

145.00 ± 5.69*

113.70 ± 30.56

168.70 ± 9.40*

 Na + (mmol/L)

147.60 ± 0.95

147.30 ± 0.47

147.70 ± 1.15

146.60 ± 0.84

146.20 ± 0.23

145.90 ± 0.89

145.20 ± 0.73

 K+ (mmol/L)

6.71 ± 0.18

5.87 ± 0.15

5.26 ± 0.38*

5.81 ± 0.20

5.74 ± 0.26

5.62 ± 0.05*

5.98 ± 0.20

 Cl-(mmol/L)

111.11 ± 0.55

147.30 ± 3.00*

139.70 ± 10.82*

133.30 ± 9.91*

102.80 ± 0.42*

104.30 ± 0.69*

104.90 ± 0.55*

Males

 CREAT (mg/dL)

0.56 ± 0.06

0.53 ± 0.08

0.42 ± 0.12

0.30 ± 0.01

0.76 ± 0.10

0.76 ± 0.08

0.75 ± 0.10

 Urea (mg/dL)

42.13 ± 4.42

46.23 ± 1.69

48.70 ± 5.81

46.90 ± 6.48

42.40 ± 2.95

42.57 ± 2.45

33.27 ± 5.76

 ALT (U/L)

80.00 ± 6.81

66.33 ± 4.67

61.33 ± 10.17

69.33 ± 8.11

122.7 ± 19.46

115.70 ± 4.91

104.00 ± 9.24

 AST (U/L)

142.30 ± 22.60

128.30 ± 15.10

138.70 ± 20.93

122.00 ± 4.16

138.00 ± 6.43

134.70 ± 7.06

139.30 ± 28.39

 Tot Chol (mg/dL)

51.00 ± 7.37

44.00 ± 6.03

36.67 ± 0.88

44.33 ± 9.33

70.00 ± 22.27

129.70 ± 8.41*

117.30 ± 4.67*

 Na + (mmol/L)

148.00 ± 1.80

148.10 ± 0.78

146.70 ± 1.07

148.60 ± 0.41

147.00 ± 0.56

145.80 ± 0.85

146.00 ± 0.28

 K+ (mmol/L)

7.17 ± 0.05

6.25 ± 0.26

6.93 ± 0.56

6.13 ± 0.15

6.38 ± 0.09

6.62 ± 0.66

6.76 ± 0.67

 Cl-(mmol/L)

111.60 ± 5.11

161.90 ± 5.51*

151.00 ± 2.56*

163.20 ± 3.63*

104.80 ± 0.84

105.30 ± 0.17

105.80 ± 1.47

  1. Data are expressed as Mean ± SEM; **significant p-value when control is compared with treatment groups (male and female combined); *significant p-value when control is compared with treatment groups (male and female separated) n (number of rats) =6/group for treated groups while 5/group for control for the combined analysis while n = 3/group for the separate group analysis