Biochemical parameters | Control group | A. vera whole leaf extract dose levels in mg/kg | A. vera green rind extract dose levels in mg/kg | ||||
---|---|---|---|---|---|---|---|
200 | 400 | 800 | 200 | 400 | 800 | ||
Combined male and female | |||||||
 CREAT (mg/dl) | 0.57 ± 0.03 | 0.48 ± 0.04 | 0.42 ± 0.06 | 0.49 ± 0.09 | 0.86 ± 0.07** | 0.85 ± 0.06** | 0.83 ± 0.06** |
 Urea (mg/dl) | 44.90 ± 3.16 | 48.42 ± 2.70 | 48.38 ± 2.80 | 44.32 ± 3.20 | 50.15 ± 4.63 | 45.40 ± 3.22 | 38.57 ± 3.58 |
 ALT (U/L) | 69.40 ± 8.19 | 65.83 ± 2.36 | 60.17 ± 5.08 | 70.50 ± 4.72 | 104.00 ± 12.86 | 87.50 ± 13.02 | 102.50 ± 11.18 |
 AST (U/L) | 147.40 ± 13.08 | 138.50 ± 10.82 | 139.70 ± 9.53 | 125.70 ± 2.86 | 136.00 ± 4.41 | 128.00 ± 10.13 | 155.80 ± 15.03 |
 Tot Chol (mg/dl) | 50.40 ± 4.08 | 54.17 ± 5.65 | 41.67 ± 3.45 | 52.50 ± 5.93 | 107.50 ± 19.67 | 121.70 ± 14.62** | 143.0 ± 12.40** |
 Na + (mmol/l) | 147.80 ± 1.04 | 147.70 ± 0.45 | 147.20 ± 0.74 | 147.60 ± 0.61 | 146.60 ± 0.32 | 145.90 ± 0.55 | 145.60 ± 0.39 |
 K+ (mmol/l) | 6.98 ± 0.13 | 6.06 ± 0.16 | 6.10 ± 0.48 | 5.97 ± 0.13 | 6.06 ± 0.19 | 6.12 ± 0.37 | 6.37 ± 0.36 |
 Cl- (mmol/l) | 111.40 ± 2.81 | 154.60 ± 4.29** | 145.30 ± 5.58** | 148.20 ± 8.18** | 103.80 ± 0.61** | 104.80 ± 0.39** | 105.30 ± 0.73** |
Females | |||||||
 CREAT (mg/dL) | 0.58 ± 0.02 | 0.43 ± 0.03 | 0.41 ± 0.05 | 0.67 ± 0.06 | 0.95 ± 0.09* | 0.93 ± 0.06* | 0.90 ± 0.02* |
 Urea (mg/dL) | 49.05 ± 3.55 | 50.60 ± 5.36 | 48.07 ± 2.35 | 41.73 ± 1.61 | 57.90 ± 6.21 | 48.23 ± 6.15 | 43.87 ± 1.72 |
 ALT (U/L) | 53.50 ± 10.50 | 65.33 ± 2.40 | 59.00 ± 4.93 | 71.67 ± 6.64 | 85.33 ± 9.96 | 59.33 ± 5.49 | 101.00 ± 23.18 |
 AST (U/L) | 155.00 ± 9.00 | 148.7 ± 15.94 | 140.70 ± 3.84 | 129.30 ± 3.18 | 134.00 ± 7.21 | 121.30 ± 20.46 | 172.30 ± 7.22 |
 Tot Chol (mg/dL) | 49.05 ± 1.50 | 64.33 ± 4.49 | 46.67 ± 5.81 | 60.67 ± 4.67 | 145.00 ± 5.69* | 113.70 ± 30.56 | 168.70 ± 9.40* |
 Na + (mmol/L) | 147.60 ± 0.95 | 147.30 ± 0.47 | 147.70 ± 1.15 | 146.60 ± 0.84 | 146.20 ± 0.23 | 145.90 ± 0.89 | 145.20 ± 0.73 |
 K+ (mmol/L) | 6.71 ± 0.18 | 5.87 ± 0.15 | 5.26 ± 0.38* | 5.81 ± 0.20 | 5.74 ± 0.26 | 5.62 ± 0.05* | 5.98 ± 0.20 |
 Cl-(mmol/L) | 111.11 ± 0.55 | 147.30 ± 3.00* | 139.70 ± 10.82* | 133.30 ± 9.91* | 102.80 ± 0.42* | 104.30 ± 0.69* | 104.90 ± 0.55* |
Males | |||||||
 CREAT (mg/dL) | 0.56 ± 0.06 | 0.53 ± 0.08 | 0.42 ± 0.12 | 0.30 ± 0.01 | 0.76 ± 0.10 | 0.76 ± 0.08 | 0.75 ± 0.10 |
 Urea (mg/dL) | 42.13 ± 4.42 | 46.23 ± 1.69 | 48.70 ± 5.81 | 46.90 ± 6.48 | 42.40 ± 2.95 | 42.57 ± 2.45 | 33.27 ± 5.76 |
 ALT (U/L) | 80.00 ± 6.81 | 66.33 ± 4.67 | 61.33 ± 10.17 | 69.33 ± 8.11 | 122.7 ± 19.46 | 115.70 ± 4.91 | 104.00 ± 9.24 |
 AST (U/L) | 142.30 ± 22.60 | 128.30 ± 15.10 | 138.70 ± 20.93 | 122.00 ± 4.16 | 138.00 ± 6.43 | 134.70 ± 7.06 | 139.30 ± 28.39 |
 Tot Chol (mg/dL) | 51.00 ± 7.37 | 44.00 ± 6.03 | 36.67 ± 0.88 | 44.33 ± 9.33 | 70.00 ± 22.27 | 129.70 ± 8.41* | 117.30 ± 4.67* |
 Na + (mmol/L) | 148.00 ± 1.80 | 148.10 ± 0.78 | 146.70 ± 1.07 | 148.60 ± 0.41 | 147.00 ± 0.56 | 145.80 ± 0.85 | 146.00 ± 0.28 |
 K+ (mmol/L) | 7.17 ± 0.05 | 6.25 ± 0.26 | 6.93 ± 0.56 | 6.13 ± 0.15 | 6.38 ± 0.09 | 6.62 ± 0.66 | 6.76 ± 0.67 |
 Cl-(mmol/L) | 111.60 ± 5.11 | 161.90 ± 5.51* | 151.00 ± 2.56* | 163.20 ± 3.63* | 104.80 ± 0.84 | 105.30 ± 0.17 | 105.80 ± 1.47 |