Table 3 Effects of M. pruriens extract on selected biomarkers (AST, ALT, ALP and T. BIL.) in the liver and kidney of rats after CCl₄ and rifampicin induced toxicity

AST (IU/l)

Liver

54.33 ± 2.31^a

82.31 ± 2.47

62.13 ± 0.14^a

52.93 ± 0.10^a

57.23 ± 1.53^a

96.14 ± 2.41

71.52 ± 2.15^a

58.77 ± 1.87^a

Kidney

21.60 ± 2.07^a

37.81 ± 1.02

30.60 ± 1.12^a

26.34 ± 1.08^a

25.06 ± 1.20^a

56.82 ± 1.73

38.62 ± 1.63^a

28.26 ± 1.29^a

Serum

71.26 ± 1.71^a

115.63 ± 1.67

93.74 ± 1.88^a

78.14 ± 0.98^a

75.22 ± 1.56^a

127.13 ± 2.60

112.31 ± 3.11^a

92.14 ± 2.34^a

ALT (IU/l)

Liver

40.71 ± 1.32^a

64.21 ± 1.43

55.81 ± 1.16^a

50.04 ± 2.01^a

51.33 ± 1.1^a

77.23 ± 1.42

62.49 ± 1.98^a

42.03 ± 1.58^a

Kidney

17.27 ± 0.25^a

30.44 ± 0.97

24.16 ± 0.84^a

20.03 ± 0.29^a

23.63 ± 1.23^a

40.29 ± 1.77

36.29 ± 1.23^a

23.60 ± 2.01^a

Serum

56.17 ± 1.98^a

92.76 ± 1.23

72.10 ± 2.13^a

64.40 ± 2.22^a

59.33 ± 1.34^a

88.45 ± 2.43

62.75 ± 2.00^a

59.22 ± 1.96^a

ALP (IU/l)

Liver

47.25 ± 1.92^a

58.78 ± 1.63

51.06 ± 1.35

42.53 ± 1.07^a

46.88 ± 0.49^a

73.84 ± 0.81

64.67 ± 0.92^a

49.22 ± 0.67^a

Kidney

31.21 ± 1.25^a

48.17 ± 0.84

33.09 ± 0.92^a

26.04 ± 0.88^a

29.32 ± 0.98^a

53.66 ± 1.98

44.36 ± 1.72^a

34.83 ± 1.45^a

Serum

62.13 ± 3.12 ^a

102.43 ± 4.20

82.42 ± 2.00^a

71.38 ± 1.86^a

67.11 ± 2.09^a

108.52 ± 1.32

81.57 ± 2.07^a

68.34 ± 1.82^a

T. Bil

Liver

31.18 ± 4.04^a

44.37 ± 3.54

37.25 ± 2.10^a

30.34 ± 2.08^a

31.72 ± 0.82^a

56.18 ± 0.54

42.33 ± 0.61^a

32.40 ± 0.50^a

Serum

42.25 ± 1.43^a

72.18 ± 1.54

58.93 ± 1.43^a

48.52 ± 1.37^a

45.37 ± 1.84^a

69.30 ± 1.02

53.26 ± 2.01^a

43.17 ± 1.33^a