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Table 2 Effects of M. pruriens extract on lipid profile in the liver and kidney of rats after CCl4 and rifampicin induced toxicity

From: Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat

Parameters

Tissues

Negative Control

Positive Control (CCl4 only)

CCl4 + 50 mg/kg b.w MP

CCl4 + 100 mg/kg b.w MP

CCl4 + 100 mg/kg b.w Silymarin

Negative Control II (Rifampicin only)

Rifampicin + 50 mg/kg b.w MP

Rifampicin + 100 mg/kg b.w MP

T. Chol (mg/dl)

Liver

56.08 ± 2.09a

89.12 ± 1.73

64.22 ± 1.23a

53.25 ± 1.06a

52.33 ± 1.34a

97.23 ± 1.42

66.40 ± 2.15a

58.29 ± 1.76a

Kidney

30.07 ± 2.18a

41.86 ± 2.09

33.22 ± 2.03a

27.63 ± 1.97a

38.63 ± 2.23a

53.24 ± 1.03

46.32 ± 1.23a

34.04 ± 1.16a

Serum

52.16 ± 2.19a

72.44 ± 1.86

61.32 ± 1.36a

56.82 ± 1.45a

58.27 ± 1.56a

87.46 ± 1.38

64.03 ± 1.02a

59.34 ± 2.16a

Trig. (mg/dl)

Liver

41.33 ± 1.07a

70.25 ± 1.24

51.27 ± 1.39a

43.76 ± 1.22a

39.43 ± 1.13a

86.50 ± 0.42

71.49 ± 0.63a

60.08 ± 1.23a

Kidney

11.82 ± 0.34a

19.47 ± 0.42

14.06 ± 0.77a

12.93 ± 0.64a

13.43 ± 0.29a

26.48 ± 0.33

20.13 ± 0.29a

16.25 ± 0.20a

Serum

37.51 ± 1.39a

61.41 ± 1.28

50.14 ± 1.07a

42.66 ± 1.33a

40.14 ± 1.72a

70.39 ± 1.45

53.86 ± 2.09a

46.25 ± 1.77a

HDL (mg/dl)

Liver

24.72 ± 0.44a

16.07 ± 0.53

20.15 ± 0.68a

22.43 ± 0.53a

26.31 ± 0.59a

18.26 ± 0.24

21.72 ± 0.66a

23.18 ± 0.52a

Kidney

8.26 ± 0.17a

5.31 ± 0.87

8.12 ± 0.56a

8.51 ± 0.53a

8.42 ± 0.68a

6.08 ± 0.63

6.83 ± 0.53a

7.27 ± 0.76a

Serum

9.42 ± 0.31a

6.37 ± 0.43

7.00 ± 0.81a

7.82 ± 0.70a

8.79 ± 0.29a

5.10 ± 0.07

8.15 ± 0.05a

8.86 ± 0.02a

LDL (mg/dl)

Liver

33.76 ± 1.27a

41.27 ± 1.53

36.09 ± 1.31a

32.47 ± 0.78a

33.04 ± 0.62a

57.81 ± 0.11

48.06 ± 0.37a

39.16 ± 0.25a

Kidney

13.26 ± 0.73a

21.60 ± 0.82

16.01 ± 0.69a

14.07 ± 0.43a

12.13 ± 0.48a

31.27 ± 0.57

24.12 ± 0.54a

19.33 ± 0.66a

Serum

22.36 ± 0.32a

34.26 ± 0.53

26.42 ± 0.34a

22.14 ± 0.13a

24.67 ± 0.72a

39.53 ± 0.68

30.06 ± 0.51a

23.72 ± 0.44a

  1. Data shows mean ± SEM values of four independent experiments performed in triplicate ‘a’ represents significant difference (p < 0.05) from the control, (n = 5)