Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

Table 7 Histopathological nephrotoxicity scores of the experimental groups

Group	Glomerular damage						Tubular damage						Tubulointerstitial inflammatory infiltrate				Total nephrotoxicity score	Average
Group	G0	G1	G2	G3	G4	Average	G0	G1	G2	G3	G4	Average	G0	G1	G2	Average	Total nephrotoxicity score	Average
1. Control	7	0	0	0	0	0.0	7	0	0	0	0	0.0	7	0	0	0.0	0	0.0
2. PREOG	7	0	0	0	0	0.0	7	0	0	0	0	0.0	7	0	0	0.0	0	0.0
3. CP	4	0	1	1	1	0.60*	3	0	1	1	2	1.40*	5	0	2	0.48*	7	0.76*
4. PREOG + CP	6	1	0	0	0	0.20^#	6	1	0	0	0	0.20^#	6	1	0	0.20^#	2	0.12^#

Total score of 0–2 represents none/mild nephrotoxicity, 3–6 moderate nephrotoxicity, 7–10 severe nephrotoxicity
G Grade
Each value represents mean ± SEM (n = 7). * (p < 0.05) = significantly different from control. ^# (p < 0.05) = significantly different from CP (50 mg/kg)

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