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Table 3 Results of α-glucosidase, α-amylase and PTP1B inhibitions of isolated compounds from w

From: Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches

Compound

Mol wt

Conc (μg/mL)

α-Glucosidase results

α-Amylase results

PTP1B results

Percent Inhibition

(mean ± SEM)

IC50

(μg/mL)

IC50 (μM)

Percent Inhibition

(mean ± SEM)

IC50

(μg/mL)

IC50 (μM)

Percent Inhibition

(mean ± SEM)

IC50

(μg/mL)

IC50 (μM)

Nt01

216

500

250

125

62.50

31.25

55.56 ± 1.06***

51.90 ± 0.45***

44.40 ± 0.82***

31.33 ± 0.66*

21.42 ± 0.43ns

272.82

58.93

77.85 ± 2.24***

72.08 ± 0.47***

67.90 ± 0.96***

63.28 ± 0.57***

57.47 ± 0.56***

12.15

56.25

90.09 ± 0.32***

88.67 ± 1.20***

83.40 ± 0.25***

78.58 ± 1.12***

74.65 ± 1.34***

2.80

12.96

Nt02

112

500

250

125

62.50

31.25

76.85 ± 2.24***

71.08 ± 0.47***

66.90 ± 0.96***

61.35 ± 0.51***

57.40 ± 0.76***

12.87

114.93

91.36 ± 0.49ns

85.34 ± 0.55*

78.39 ± 0.49**

72.47 ± 0.52*

67.44 ± 0.55***

10.81

96.54

93.03 ± 0.48*

90.90 ± 0.48*

85.79 ± 0.63**

79.67 ± 0.61***

75.69 ± 0.77***

4.06

36.22

Nt03

430

500

250

125

62.50

31.25

78.35 ± 0.23***

73.36 ± 0.84***

70.62 ± 0.25***

66.16 ± 0.16***

59.67 ± 0.32***

8.40

19.54

93.08 ± 1.04ns

86.45 ± 0.90ns

80.58 ± 0.63ns

73.40 ± 0.20ns

67.80 ± 0.90*

10.49

24.39

90.83 ± 0.47***

87.23 ± 0.96***

82.29 ± 0.57***

78.33 ± 0.55***

76.03 ± 0.77***

1.54

3.57

Acarbose

645

500

250

125

62.50

31.25

87.08 ± 0.47

82.40 ± 0.20

77.61 ± 0.43

75.45 ± 0.90

63.89 ± 0.20

6.84

10.60

95.23 ± 0.22

89.45 ± 0.90

83.90 ± 0.60

77.00 ± 0.30

72.90 ± 0.45

8.20

12.71

Ursolic acid

98.65 ± 1.32

93.56 ± 0.45

91.52 ± 0.66

88.22 ± 1.28

86.42 ± 0.43

1.66

3.63