Compound | Mol wt | Conc (μg/mL) | α-Glucosidase results | α-Amylase results | PTP1B results | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Percent Inhibition (mean ± SEM) | IC50 (μg/mL) | IC50 (μM) | Percent Inhibition (mean ± SEM) | IC50 (μg/mL) | IC50 (μM) | Percent Inhibition (mean ± SEM) | IC50 (μg/mL) | IC50 (μM) | |||
Nt01 | 216 | 500 250 125 62.50 31.25 | 55.56 ± 1.06*** 51.90 ± 0.45*** 44.40 ± 0.82*** 31.33 ± 0.66* 21.42 ± 0.43ns | 272.82 | 58.93 | 77.85 ± 2.24*** 72.08 ± 0.47*** 67.90 ± 0.96*** 63.28 ± 0.57*** 57.47 ± 0.56*** | 12.15 | 56.25 | 90.09 ± 0.32*** 88.67 ± 1.20*** 83.40 ± 0.25*** 78.58 ± 1.12*** 74.65 ± 1.34*** | 2.80 | 12.96 |
Nt02 | 112 | 500 250 125 62.50 31.25 | 76.85 ± 2.24*** 71.08 ± 0.47*** 66.90 ± 0.96*** 61.35 ± 0.51*** 57.40 ± 0.76*** | 12.87 | 114.93 | 91.36 ± 0.49ns 85.34 ± 0.55* 78.39 ± 0.49** 72.47 ± 0.52* 67.44 ± 0.55*** | 10.81 | 96.54 | 93.03 ± 0.48* 90.90 ± 0.48* 85.79 ± 0.63** 79.67 ± 0.61*** 75.69 ± 0.77*** | 4.06 | 36.22 |
Nt03 | 430 | 500 250 125 62.50 31.25 | 78.35 ± 0.23*** 73.36 ± 0.84*** 70.62 ± 0.25*** 66.16 ± 0.16*** 59.67 ± 0.32*** | 8.40 | 19.54 | 93.08 ± 1.04ns 86.45 ± 0.90ns 80.58 ± 0.63ns 73.40 ± 0.20ns 67.80 ± 0.90* | 10.49 | 24.39 | 90.83 ± 0.47*** 87.23 ± 0.96*** 82.29 ± 0.57*** 78.33 ± 0.55*** 76.03 ± 0.77*** | 1.54 | 3.57 |
Acarbose | 645 | 500 250 125 62.50 31.25 | 87.08 ± 0.47 82.40 ± 0.20 77.61 ± 0.43 75.45 ± 0.90 63.89 ± 0.20 | 6.84 | 10.60 | 95.23 ± 0.22 89.45 ± 0.90 83.90 ± 0.60 77.00 ± 0.30 72.90 ± 0.45 | 8.20 | 12.71 | – | – | – |
Ursolic acid | – | – | – | – | – | – | – | – | 98.65 ± 1.32 93.56 ± 0.45 91.52 ± 0.66 88.22 ± 1.28 86.42 ± 0.43 | 1.66 | 3.63 |