Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches

Mahnashi, Mater H.; Alqahtani, Yahya S.; Alqarni, Ali O.; Alyami, Bandar A.; Jan, Muhammad Saeed; Ayaz, Muhammad; Ullah, Farhat; Rashid, Umer; Sadiq, Abdul

doi:10.1186/s12906-021-03443-7

BMC Complementary Medicine and Therapies

Table 2 Results of antioxidant assays on various crude extracts of Notholirion thomsonianum

From: Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches

Samples	Conc (μg/mL)	DPPH Assay		ABTS Assay		H₂O₂ Assay
Samples	Conc (μg/mL)	% Scavenging (mean ± SEM)	IC₅₀ (μg/mL)	% Scavenging (mean ± SEM)	IC₅₀ (μg/mL)	% Scavenging (mean ± SEM)	IC₅₀ (μg/mL)
Nt.Cr	1000 500 250 125 62.5	80.10 ± 0.95* 78.70 ± 0.51* 70.93 ± 0.90* 60.43 ± 0.70* 58.26 ± 0.77***	21	71.33 ± 0.88* 64.66 ± 0.33* 61.00 ± 0.57* 56.53 ± 0.40* 52.46 ± 0.49***	57	64.86 ± 0.85* 57.63 ± 0.60* 51.96 ± 0.21* 45.53 ± 0.61* 40.63 ± 0.60***	221
Nt.Hex	1000 500 250 125 62.5	83.13 ± 0.80* 78.83 ± 0.73* 72.70 ± 0.51* 66.43 ± 0.70* 61.06 ± 0.70***	15	53.66 ± 0.88* 43.66 ± 0.66* 37.56 ± 0.46* 32.46 ± 0.49* 28.66 ± 0.66***	368	54.76 ± 0.78* 43.16 ± 0.86* 41.86 ± 0.91* 37.53 ± 1.09* 33.16 ± 0.86***	788
Nt.Chf	1000 500 250 125 62.5	88.43 ± 1.26* 83.83 ± 0.66* 77.93 ± 0.90 72.26 ± 0.77 67.10 ± 0.95*	10	74.70 ± 0.55* 66.20 ± 0.95* 62.00 ± 0.57* 55.93 ± 0.44* 48.53 ± 0.40***	72	69.00 ± 0.57* 64.33 ± 0.88* 55.06 ± 1.04* 52.00 ± 0.57* 48.53 ± 0.61***	79
Nt.EtAc	1000 500 250 125 62.5	89.96 ± 0.55 ^ns 85.93 ± 0.30 ^ns 81.40 ± 0.65 ^ns 77.46 ± 0.50 ^ns 72.10 ± 0.65 ^ns	< 0.1	67.33 ± 0.33* 65.50 ± 0.43* 61.46 ± 0.57* 53.56 ± 0.60* 46.20 ± 0.95***	89	76.43 ± 0.81* 73.56 ± 1.24^ns 68.46 ± 0.50* 63.60 ± 0.41* 58.33 ± 0.88*	16
Nt.Aq	1000 500 250 125 62.5	68.63 ± 0.70* 63.06 ± 0.60* 57.60 ± 0.87* 52.93 ± 0.50* 46.76 ± 1.00***	85	51.56 ± 0.49* 47.40 ± 0.52* 41.66 ± 0.61* 38.46 ± 0.54* 35.56 ± 0.60***	942	43.00 ± 0.57* 41.40 ± 0.64* 33.76 ± 0.52* 29.43 ± 0.59* 24.76 ± 0.52***	1403
AA	1000 500 250 125 62.5	92.55 ± 0.35 87.84 ± 0.26 81.33 ± 0.88 76.54 ± 0.54 72.67 ± 0.19	< 0.1	87.60 ± 0.40 86.53 ± 0.60 80.43 ± 0.55 78.46 ± 0.58 75.46 ± 0.57	< 0.1	83.33 ± 0.88 74.66 ± 0.49 71.50 ± 0.60 68.00 ± 0.57 65.06 ± 1.04	9.87

Back to article page

ISSN: 2662-7671

Contact us

Submission enquiries: bmccomplementarymedicineandtherapies@biomedcentral.com
General enquiries: ORSupport@springernature.com