Fig. 3
Petroleum ether extract of LF (PEL) treatment significantly alleviated synovial inflammation and cartilage erosion in adjuvant-induced arthritis (AIA) rats. A Representative HE staining images and amplification of respective typical lesions (× 100) and semiquantitative score of synovial inflammation. Black arrows point to the infiltration of inflammatory cells or synovial hyperplasia. B Representative safranin O-fast green staining images (× 100) and semiquantitative score of cartilage erosion. Red arrows point to areas of cartilage loss. Blue arrows point to areas of bone erosion. Semiquantitative scores of synovial inflammation and cartilage erosion in NC were set to 0. Data were recorded as mean ± SEM. Differences were assessed by Dunnett’s multiple comparisons test and one-way ANOVA, **P < 0.01 vs MC, ***P < 0.001 vs MC, ****P < 0.0001 vs MC. (n = 2)