Table 5 IC50 of combination treatment of NaDCM (1.5 μg/mL) with various concentration of antiHCV drug
NaDCM (1.5 μg/mL) | |||||
Ribavirin | Cyclosporin | ||||
Conc (ug/mL) | IC50 | combination treatment | Conc (ug/mL) | IC50 | combination treatment |
40.00 | < 0,1 | Syn | 2.40 | < 0,03 | Syn |
20.00 | < 0,1 | Syn | 1.20 | 0,03 ± 0,03 | Syn |
10.00 | 0.32 | Syn | 0.60 | 0,19 ± 0,12 | Syn |
5.00 | 0.47 | Syn | 0.30 | 1,20 ± 0,60 | Ant |
2.50 | 0,4 ± 0,3 | Syn | 0.10 | 1,63 ± 0,17 | Ant |
NaDCM (1.5 μg/mL) | |||||
Simaprevir | Telaprevir | ||||
Conc (nM) | IC50 | combination treatment | Conc (nM) | IC50 | combination treatment |
160.00 | < 0,7 | Syn | 40.00 | 0,21 ± 0,15 | Ant |
80.00 | < 0,7 | Syn | 20.00 | 0,75 ± 0,06 | Ant |
40.00 | < 0,7 | Syn | 10.00 | 0,9 ± 0,1 | Ant |
20.00 | < 0,7 | Syn | 5.00 | 1,42 ± 0,07 | Ant |
10.00 | 0,83 ± 0,33 | Ant | 2.50 | 1,22 ± 0,09 | Ant |