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Table 2 Inhibitory activities of crude extracts and isolated compounds against P. falciparum, T. brucei rhodesiense, and M. tuberculosis

From: Isolation of bioactive compounds from medicinal plants used in traditional medicine: Rautandiol B, a potential lead compound against Plasmodium falciparum

Compounds (μM)
Crude Extracts (μg/mL)
MTB H37Rv (MIC μM) T. br (IC50 μM) P. f (IC50 μM)
TM4/8.2 K1CB1
ABDCM > 20 3.04 ± 0.27 2.99 ± 0.59
SR −0.9
2.67 ± 1.05
SR −1.01
KEOH > 20 18.14 ± 1.34 > 50 > 50
CEOH > 20 22.89 ± 1.29 > 50 > 50
1 > 20 8.74 ± 0.49
SR - 3.3
> 50 > 50
2 > 20 8.91 ± 0.03
SR - 4.52
> 50 > 50
3 > 20 > 100 > 100 > 100
4 > 20 > 100 > 100 > 100
5 > 62.1 > 31.0 > 31.0
6 > 64.9 > 32.5 > 32.5
7 > 34.4 > 17.2 > 17.2
10 > 64.7 > 32.3 > 32.3
11 > 62.0 17.01 ± 1.83 > 31.0 > 31.0
13 > 56.9 > 28.5 > 28.5
14 > 59.9 18.65 ± 3.20 > 29.6 > 29.6
15 > 56.8 4.87 ± 0.49
SR > 5.83
> 28.4 > 28.4
16 > 56.4 > 28.2 > 28.2
19 > 56.8 > 28.4 > 28.4
20 > 52.3 7.51 ± 0.17 > 26.2 > 26.2
21 > 55.2 8.63 ± 1.14 > 27.6 > 27.6
22 > 61.7 > 30.9 > 30.9
24 > 20 23.54 ± 1.59 0.40 ± 0.07
SR −108
0.74 ± 0.29
SR −133
Isoniazid 0.02
Rifampin 0.08
Cycloguanil 0.076 ± 0.016 10.7 ± 1.62
Pyrimethamine   0.095 ± 0.02 23.21 ± 2.24
Pentamidine 0.007 ± 0.00004
  1. Abbreviations: MTB Mycobacterium tuberculosis, T. br Trypanosoma brucei rhodesience, P. f Plasmodium falciparum, SR Safety ratio