Table 2 Inhibitory activities of crude extracts and isolated compounds against P. falciparum, T. brucei rhodesiense, and M. tuberculosis
Compounds (μM) Crude Extracts (μg/mL) | MTB H37Rv (MIC μM) | T. br (IC50 μM) | P. f (IC50 μM) | |
|---|---|---|---|---|
TM4/8.2 | K1CB1 | |||
ABDCM | > 20 | 3.04 ± 0.27 | 2.99 ± 0.59 SR −0.9 | 2.67 ± 1.05 SR −1.01 |
KEOH | > 20 | 18.14 ± 1.34 | > 50 | > 50 |
CEOH | > 20 | 22.89 ± 1.29 | > 50 | > 50 |
1 | > 20 | 8.74 ± 0.49 SR - 3.3 | > 50 | > 50 |
2 | > 20 | 8.91 ± 0.03 SR - 4.52 | > 50 | > 50 |
3 | > 20 | > 100 | > 100 | > 100 |
4 | > 20 | > 100 | > 100 | > 100 |
5 | > 62.1 | – | > 31.0 | > 31.0 |
6 | > 64.9 | – | > 32.5 | > 32.5 |
7 | > 34.4 | – | > 17.2 | > 17.2 |
10 | > 64.7 | – | > 32.3 | > 32.3 |
11 | > 62.0 | 17.01 ± 1.83 | > 31.0 | > 31.0 |
13 | > 56.9 | – | > 28.5 | > 28.5 |
14 | > 59.9 | 18.65 ± 3.20 | > 29.6 | > 29.6 |
15 | > 56.8 | 4.87 ± 0.49 SR > 5.83 | > 28.4 | > 28.4 |
16 | > 56.4 | – | > 28.2 | > 28.2 |
19 | > 56.8 | – | > 28.4 | > 28.4 |
20 | > 52.3 | 7.51 ± 0.17 | > 26.2 | > 26.2 |
21 | > 55.2 | 8.63 ± 1.14 | > 27.6 | > 27.6 |
22 | > 61.7 | – | > 30.9 | > 30.9 |
24 | > 20 | 23.54 ± 1.59 | 0.40 ± 0.07 SR −108 | 0.74 ± 0.29 SR −133 |
Isoniazid | 0.02 | – | – | – |
Rifampin | 0.08 | – | – | – |
Cycloguanil | – | – | 0.076 ± 0.016 | 10.7 ± 1.62 |
Pyrimethamine | – |  | 0.095 ± 0.02 | 23.21 ± 2.24 |
Pentamidine | – | 0.007 ± 0.00004 | – | – |