Fig. 5From: In vitro inhibitory effect of obtusofolin on the activity of CYP3A4, 2C9, and 2E1Obtusofolin inhibited the activity of CYP3A4 in a time-dependent manner. A Linear regression analysis on the activity versus incubation time in the presence of 0, 2, 5, 20, and 50 μM obtusofolin. B Non-linear analysis on the initial rate constant versus the concentration of obtusofolin to obtain the value of KI and KinactBack to article page