Fig. 7

Proteomic analysis of unique differentially expressed proteins by MCF7 breast cancer cell lines after combined treatment with IR and MPSE. A Heat map displaying changes in protein levels in MCF7 cells treated with IR, and MCF7 cells combined treated with IR and MPSE; 41 differentially (fold change ≥1.5, p < 0.05) expressed proteins in MCF7 cells combined treated with MPSE and IR. B Protein network presenting the functional protein–protein interactions of the 41 differentially expressed proteins in MCF7 cells combined treated with MPSE and IR using STRING (v.11.0) software. The three clusters of protein nodes that closely and frequently interacted are indicated by circles. They include proteins involved in the cellular response to DNA damage, apoptosis induction, and PI3K/AKT signaling pathways