Table 4 Effects of the crude extract, fractions, and subfractions of I. dipyrena on formalininduced paw-licking response
From: Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice
Treatment | Dose | Licking time (Sec) | Inhibition (%) | ||
|---|---|---|---|---|---|
1st Phase | 2nd Phase | 1st Phase | 2nd Phase | ||
Control | 2% Tween-80 | 41.22 ± 1.68 | 62.11 ± 1.86 | – | – |
Crd-Id | 100 | 23.88 ± 1.65* | 26.96 ± 1.74* | 42.06 | 56.58 |
Crd-Id | 200 | 21.85 ± 2.05*** | 21.66 ± 1.38*** | 46.99 | 65.11 |
Chl-Id | 75 | 19.66 ± 1.48*** | 20.24 ± 1.21*** | 52.29 | 67.41 |
Et-Id | 75 | 24.18 ± 1.76*** | 23.13 ± 1.99*** | 41.32 | 63.29 |
Fr.Chl-Id 46 | 75 | 24.68 ± 1.86** | 25.33 ± 1.61** | 40.12 | 59.21 |
Fr.Chl-Id 47 | 75 | 23.46 ± 1.81*** | 22.28 ± 1.91*** | 43.07 | 64.12 |
Fr.Chl-Id 48 | 75 | 20.36 ± 1.38*** | 20.14 ± 1.22*** | 50.59 | 67.57 |
Indomethacin | 10 mg | 35.58 ± 1.92ns | 15.57 ± 1.25*** | 13.68 | 74.81 |
Morphine | 5 mg | 5.66 ± 1.42*** | 3.85 ± 1.22*** | 74.06 | 93.78 |