Fig. 2

Predicted binding modes of active compounds, artesunate and chloroquine with PfLDH. The backbones of PfLDH enzyme are depicted in green ribbon models and all hydrogen bonding residues are shown as stick models and labeled by heteroatom; white for H, blue for N, red for O. Compounds are labeled by heteroatom; yellow for C, brown for H, cyan for N, magenta for O. Hydrogen bond interactions are shown as red dash lines and represent bond length in angstrom (A°). a Artesunate. b Chloroquine. c 3,5-Dimethoxyquercetin. d Quercetin. e 2,4,3′,5′-Tetrahydroxybibenzyl. f Quercetin-3-O-β-D-galactopyranoside