Group | β-catenin | GSK-3β | E-cadherin | N-cadherin | MMP-2 | MMP-9 | Snail |
---|---|---|---|---|---|---|---|
Model control | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
5-Fu | 0.54 ± 0.02** | 3.53 ± 1.05** | 3.85 ± 0.94** | 0.46 ± 0.15** | 0.21 ± 0.01** | 0.55 ± 0.08* | 0.47 ± 0.15** |
Low-dose | 0.53 ± 0.18** | 3.00 ± 0.95* | 4.95 ± 0.37** | 0.24 ± 0.12** | 0.46 ± 0.06** | 0.66 ± 0.30* | 0.85 ± 0.19 |
Medium-dose | 0.74 ± 0.05 | 3.66 ± 1.13** | 3.76 ± 0.69** | 0.38 ± 0.18** | 0.39 ± 0.10** | 0.36 ± 0.24** | 0.43 ± 0.08** |
High-dose | 0.85 ± 0.08 | 4.19 ± 0.39** | 3.52 ± 0.66** | 0.18 ± 0.07** | 0.74 ± 0.16* | 0.22 ± 0.07** | 0.56 ± 0.25** |