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Table 5 Relative mRNA levels of specific genes involved in EMT and Wnt/β-catenin signaling pathway in SGC-7901 xenograft tumor tissues (x ± s, n = 3)

From: A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial–mesenchymal transition via the canonical Wnt/β-catenin signaling pathway

Group

β-catenin

GSK-3β

E-cadherin

N-cadherin

MMP-2

MMP-9

Snail

Model control

1

1

1

1

1

1

1

5-Fu

0.54 ± 0.02**

3.53 ± 1.05**

3.85 ± 0.94**

0.46 ± 0.15**

0.21 ± 0.01**

0.55 ± 0.08*

0.47 ± 0.15**

Low-dose

0.53 ± 0.18**

3.00 ± 0.95*

4.95 ± 0.37**

0.24 ± 0.12**

0.46 ± 0.06**

0.66 ± 0.30*

0.85 ± 0.19

Medium-dose

0.74 ± 0.05

3.66 ± 1.13**

3.76 ± 0.69**

0.38 ± 0.18**

0.39 ± 0.10**

0.36 ± 0.24**

0.43 ± 0.08**

High-dose

0.85 ± 0.08

4.19 ± 0.39**

3.52 ± 0.66**

0.18 ± 0.07**

0.74 ± 0.16*

0.22 ± 0.07**

0.56 ± 0.25**

  1. Data are expressed as fold change. *p < 0.05 vs. model control; **p < 0.01 vs. model control