Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS

Lin, Yan; Xiao, Rong; Xia, Bo-hou; Zhang, Zhi-min; Li, Chun; Wu, Ping; Liao, Duan-fang; Lin, Li-mei

doi:10.1186/s12906-021-03276-4

BMC Complementary Medicine and Therapies

Table 3 Serum differential metabolites and metabolic pathways in the diffirent groups

From: Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS

No	t/min	Metabolites	m/z	Trend				Metabolic pathways
No	t/min	Metabolites	m/z	M	CPHL	FHL	TSGHL	Metabolic pathways
1	6.544	4-Methylvaleric acid	116.16
2	6.924	Propanoic acid	74.00
3	7.414	L-Valine	117.15	↓¹⁾	↓²⁾	↓²⁾	↓²⁾	Amino acid metabolism
4	7.811	Alanine	89.09	↑¹⁾				Amino acid metabolism
5	8.214	Glycine	75.07			↑²⁾		Amino acid metabolism
6	8.518	3-Hydroxybutyric acid	104.11		↑²⁾	↑²⁾	↑²⁾	Energetic metabolism
7	8.818	L-Leucine	116.16	↓¹⁾	↓²⁾			Amino acid metabolism
8	9.444	Methoxyacetlc acid	89.07
9	9.964	Urea	60.06		↑²⁾	↑²⁾	↑²⁾	Microbial metabolism
10	10.09	L-Serine	105.09
11	10.67	L-Threonine	119.09	↓¹⁾				Amino acid metabolism
12	10.88	3-Aminoisobutyric acid	103.12
13	12.124	Hexadecanoic acid	116.16		↑²⁾		↑²⁾	Glucose metabolism
14	12.198	Methoxyacetic acid	90.08
15	13.514	DL-Methionine	131.17
16	13.809	DL-Malic acid	134.09
17	14.364	L-Proline	115.13	↓¹⁾			↓²⁾	Amino acid metabolism
18	16.648	Ribitol	152.15
19	17.155	Sulfurous	82.08
20	18.709	Citric Acid	192.12	↓¹⁾		↑²⁾	↑²⁾	Glucose metabolism
21	19.608	D-Mannose	180.16		↑²⁾	↑²⁾	↑²⁾	Glucose metabolism
22	19.759	D-Glucose	180.16		↑²⁾	↑²⁾		Carbohydrate metabolism
23	20.026	D-Galactose	180.16	↓¹⁾	↑²⁾	↑²⁾	↑²⁾	Glucosemetabolism
24	21.826	Palmitic Acid	256.42
25	22.27	Inositol	180.16
26	22.802	Hexadecane	224.43
27	23.845	Octadecane	254.49		↑²⁾		↑²⁾	Fatty acid biosynthesis
28	23.92	Oleic acid	282.46			↑²⁾		Amino acid metabolism
29	24.215	Octadecanoic acid	284.48
30	25.33	Cholesterol	386.65
31	25.629	Arachidonic acid	304.46
32	28.174	Hexadecanoic acid	256.42			↑²⁾		Amino acid metabolism

Notes: LPS model group (M) vs. Negative control group, ¹⁾ p<0.01, Lipopolysaccharide (LPS) + PM high dose group (CPHL), LPS + 50% ethanol elution fraction high dose group (FHL), LPS + TSG high dose groups (TSGHL) vs. LPS model group respectively, ²⁾ p<0.01. ↑-Increase, ↓-Decrease

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ISSN: 2662-7671

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