Fig. 4

Tanshinone IIA (TIIA) + cyclosporine A (CsA) preserved myocardial mitochondrial function in renal ischemia-reperfusion (IR)-induced myocardial injury. The MMP (ratio of red/green), the opening of mPAP (%), the mitochondrial ROS, the mtDNA damage (ratio of long/short fragments), the mitochondrial RCR, mitochondrial oxygen consumption rate (a), the mitochondrial respiratory chain complex enzymes (I, II, III, IV, and V), and ATP (b) were recorded above. Rats were pre-treated with TIIA alone or in combination with CsA followed by removing the right kidney and clamping of the left renal artery for 30 min and reperfusion for 24 h. Sham rats were used as control. *p < 0.05 versus sham group, ^#p < 0.05 versus IR (obese) group, ^△p < 0.05 versus TIIA group, ^▲p < 0.05 versus CsA group