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Table 2 Statistical comparisons of parasitological parameters and cure rates in mice inoculated with Trypanosoma cruzi (Y strain - TcII) treated with 100 mg/kg/day of benznidazole (BZ), the essential oil of Zingiber officinale (GEO) and the combination of the two (BZ + GEO) for 20 consecutive days, and in untreated controls (NT)

From: Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II

Parameters NT BZ GEO BZ + GEO p-value*
%INFa 100.0 100.0 100.0 100.0 NSb
PP (days)c 13.6 ± 0.4# 0.25 ± 0.1& 12.7 ± 0.6# 0.1 ± 0.1& < 0.0001
Pmaxd 160,540.0 ± 19.722.6# 270.0 ± 1.505.1& 104,400.0 ± 141.0# 90.0 ± 90.0& < 0.0001
Dpmaxe 13.8 ± 0.6# 7.3 ± 0.9& 12.4 ± 0.6# 6.0 ± 0.5& < 0.0001
%MORTf 75.0 (9/12) 8.3 (1/12) 41.7 (5/12) 0.0 (0/12) < 0.05
% of cure   0.0 (0/12) 0.0 (0/12) 0.0 (0/12) NS
  1. a infectivity rate; b not significant; c mean patent period; d maximum of parasitemia (number of trypomastigotes in 0.1 mL of blood); e day of maximum peak; f mortality rate. Different symbols (# and &) on the same line represent significant differences. Chi-square test for the analysis of proportions and the Mann-Whitney or Kruskall-Wallis tests for analysis of the means. * Values of p ≤ 0.05 were considered significant
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