Fig. 7

Pharmacological modulation of SIRT1-regulated THJ-induced anti-inflammatory activity. a. Mice were treated with the SIRT1 inhibitor sirtinol for 12 weeks and then treated with THJ. Protein expression levels of NLRP3, caspase-1 p20, and IL-1β p17 were evaluated after different treatments. b. TNF-α levels in DCM mice. c. IL-6 levels in DCM mice. Values are shown as means ± standard deviations from three different experiments. ^##P < 0.01 versus the Con group, ^**P < 0.01 versus the DCM group, ^&&P < 0.01 versus the THJ group