Fig. 10

Effects of SSB extract on HMGB1, TRAF6, TLR4, IκB, p-IκB-α, and NF-κB65 protein expression, NF-κBp65 activity, and levels of DNA-bound NF-κB65 and TLR4 in LPS/D-GalN-induced acute liver injury in mice. a Representative Western blot showing HMGB1, TRAF6, TLR4, IκB, p-IκB-α, and NF-κB65 protein expression levels in mouse liver tissue 24 h after the administration of LPS/D-GalN plus SSB extract. b Statistical summary of the densitometric analysis of HMGB1, TRAF6, TLR4, IκB, p-IκB-α, and NF-kB65 protein expression levels in mouse liver tissue 24 h after the administration of LPS/D-GalN plus SSB extract. e and f Levels of DNA-bound NF-κB65 and TLR4 in mouse liver 24 h after the administration of LPS/D-GalN plus SSB extract. Data are expressed as mean ± SD. **P < 0.01: compared with the control group; #P < 0.05 and ##P < 0.01: compared with the model group. P > 0.05: control group compared with the control treatment group