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Table 1 Definitions of the topological parameters used in the network analysis

From: A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology

Statistical characteristic

Symbol

Equation a

Degree

k

\( {k}_i=\sum \limits_{j=1}^N{e}_{ij} \)

Average degree

<k>

\( <k>=\frac{1}{N}{\sum}_{i=1}^N{k}_i \)

Average path length

L

\( L=\frac{1}{N\left(N-1\right)}\sum \limits_{i\ne j}{d}_{ij} \)

Diameter

D

D = max {dij}

Node strength

s

\( {s}_i=\sum \limits_{j\in {N}_i}{w}_{ij} \)

Dispersion of weight distribution

Y

\( {Y}_i=\sum \limits_{j\in {N}_i}{\left[\frac{w_{ij}}{s_i}\right]}^2 \)

Degree centrality

Cd

\( {C}_d=\frac{k_i}{N-1} \)

Betweenness centrality

Cb

\( {C}_b=\sum \limits_{j\left(<k\right)}^N\sum \limits_k^N\frac{g_{jk}(i)}{g_{jk}} \)

Closeness centrality

Cc

\( {C}_c=\frac{N-1}{\sum \limits_{j=1}^N{d}_{ij}} \)

  1. aN is the total number of all nodes in the network; eij is the numbers of edges from node i to j; dij is the shortest path length from node i to j; gjk is the numbers of geodesics connecting nodes j and k; Ni is the neighbor collection of node i; Wij is the edge weight between node i and j