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Table 2 Related parameters of potential target proteins of t LFT roots

From: Molecular mechanism underlying the anti-inflammatory effects of volatile components of Ligularia fischeri (Ledeb) Turcz based on network pharmacology

Uniprot ID

PDB ID

Gene names

Protein names

Betweenness Centrality

Closeness Centrality

Degree

P41182

6CQ1

BCL6

B-cell lymphoma 6 protein

0.0340

0.2275

8

P24385

1OI9

CCND1

G1/S-specific cyclin-D1

0.0277

0.2442

10

P25963

3BRT

NFKBIA

NF-kappa-B inhibitor alpha

0.0420

0.2350

18

O15111

5EBZ

CHUK

Inhibitor of nuclear factor kappa-B kinase subunit alpha

0.0221

0.2191

18

O14920

4KIK

IKBKB

Inhibitor of nuclear factor kappa-B kinase subunit beta

0.0147

0.2181

15

Q14164

6AKK

IKBKE

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

0.0051

0.2134

5

P05412

1JNM

JUN

Transcription factor AP-1

0.0504

0.2078

13

Q99558

6G4Z

MAP 3 K14

Mitogen-activated protein kinase kinase kinase 14

0.0172

0.2014

13

Q9Y6K9

3BRV

IKBKG

NF-kappa-B essential modulator

0.0558

0.2371

23

Q16236

2LZ1

NFE2L2

Nuclear factor erythroid 2-related factor 2

0.0074

0.2259

4

P04637

3DCY

TP53

Cellular tumor antigen p53

0.2135

0.2641

60

P09874

5XSR

PARP1

Poly [ADP-ribose] polymerase 1

0.0290

0.2129

11

Q86WV6

6CY7

TMEM173

Stimulator of interferon genes protein

0.0089

0.2285

8

Q04206

3QXY

RELA

Transcription factor p65

0.0207

0.2033

19

P19438

5XME

TNFRSF1A

Tumor necrosis factor receptor superfamily member 1A

0.0151

0.2131

11

Q13546

6NW2

RIPK1

Receptor-interacting serine/threonine-protein kinase 1

0.0622

0.2541

7

Q9Y4K3

1LB5

TRAF6

TNF receptor-associated factor 6

0.0774

0.2721

22

Q14790

2LR8

CASP8

Caspase-8

0.0165

0.2160

6

P48023

2NA6

FASLG

Tumor necrosis factor ligand superfamily member 6

0.0098

0.2033

4

Q13191

2LDR

CBLB

E3 ubiquitin-protein ligase CBL-B

0.0074

0.2479

5

Q13586

4O9B

STIM1

Stromal interaction molecule 1

0.0074

0.2116

7

P31749

4EKL

AKT1

RAC-alpha serine/threonine-protein kinase

0.0312

0.2519

13

P22004

6OMO

BMP6

Bone morphogenetic protein 6

0.0098

0.2416

5

Q13936

6DAD

CACNA1C

Voltage-dependent L-type calcium channel subunit alpha-1C

0.0194

0.2426

9

P00533

3W2S

EGFR

Epidermal growth factor receptor

0.0955

0.2920

20

Q13158

2GF5

FADD

FAS-associated death domain protein

0.0203

0.2333

8

P25445

2JFD

FAS

Tumor necrosis factor receptor superfamily member 6

0.1111

0.2545

12

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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