Fig. 4
Effects of different concentrations of FPNP on H2O2-induced changes in an intracellular reduced ratio of MMP-1(a), ELN (b) and COL-I (c) in HDF cells. The mRNA expression of related genes includes MMP-1 (d), ELN (e) and COL-I (f) in HDF cells pretreated with different concentrations of FPNP. Each mRNA is normalized to ribosomal protein GAPDH and expressed relative to the control level. Number signs indicate a highly significant difference from the control cells. ##: p< 0.01; ###: p< 0.001. Asterisks indicate a highly significant difference from the H2O2-treated cells. *: p< 0.05, **: p< 0.01