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Table 5 Effects of male treatment with PADE on offspring development

From: Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development

Parameters Study groupsa
Control, H2O PADE, 25 mg/kg PADE, 125 mg/kg
Offspring survival (mean + SD)
 Number of litters examined 12 9 9
 No. offspring/ litter at birth 8.6 + 0.9 9.3 + 0.7 11.3 + 0.6
 No. of survived offspring/litter on day 21 after birth, (%) 8.6 + 0.9 (100%) 9.3 ± 0.7 (100%) 11.3 ± 0.6 (100%)
Offspring behavioral development on day 21 after birth (mean + SD)
 Number of line crossing 45.3 + 1.3 43.8 + 3.3 47.9 + 2.5
 Head dipping 12.1 + 0.7 11.8 + 1.3 12.3 + 0,8
 Grooming 0.9 + 0.3 0.9 + 0.1 0.8 + 0.2
 Defecation 1.4 + 0.3 2.5 + 0.5 2.8 + 0.4
 Rearing 0 0.03 + 0.01 0.02 + 0.01
  1. a Male rats were treated with either H2O (control) or PADE (25 or 125 mg/kg) for 60 days before mating