Skip to main content

Table 3 Effects of sub-chronic oral administration of ICR on serum and urinary biochemical parameters in females rats

From: A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Females

ICR (mg/kg b.w.)

Control

250

500

1000

Serum creatinine (μmol/l)

53.670 ± 3.969

46.300 ± 4.210 ns

52.620 ± 2.977 ns

48.41 ± 3.930 ns

Urinary creatinine (μmol/l)

1049 ± 67.97

1159 ± 52.730ns

475.600 ± 44.200*

994.900 ± 55.250ns

Serum urea (mmol/L)

6.733 ± 0.026

6.113 ± 0.733ns

3.455 ± 0.131ns

6.762 ± 0.7427ns

Urinary urea (mmol/L)

10.739 ± 0.024

11.46 ± 1.260ns

12.100 ± 0.5764ns

12.080 ± 0.8529ns

Serum total protein (g/L)

44.800 ± 0.034

43.300 ± 0.062ns

34.500 ± 0.056ns

42.300 ± 0.007ns

Urinary total protein (g/L)

7.239 ± 0.277

6.800 ± 0.036 ns

7.687 ± 0.241 ns

6.606 ± 0.434 ns

ALT (U/L)

33.350 ± 1.521

31.650 ± 2.260 ns

35.200 ± 1.218 ns

31.830 ± 1.701 ns

AST (U/L)

74.740 ± 3.420

58.220 ± 2.019*

58.270 ± 2.399*

52.100 ± 2.895*

  1. Results were expressed as Mean ± SEM for n = 5 animals per group. *:Significantly different from the control at p < 0.05
  2. ALT Alanine aminotransferase, AST Aspartate aminotransferase, ns non significative, ICR methanol extract of the roots of Imperata cylindrica
Back to article page

BMC Complementary Medicine and Therapies

ISSN: 2662-7671

Contact us