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Table 3 Effects of sub-chronic oral administration of ICR on serum and urinary biochemical parameters in females rats

From: A botanical from the antiproliferative Cameroonian spice, Imperata cylindrica is safe at lower doses, as demonstrated by oral acute and sub-chronic toxicity screenings

Females ICR (mg/kg b.w.)
Control 250 500 1000
Serum creatinine (μmol/l) 53.670 ± 3.969 46.300 ± 4.210 ns 52.620 ± 2.977 ns 48.41 ± 3.930 ns
Urinary creatinine (μmol/l) 1049 ± 67.97 1159 ± 52.730ns 475.600 ± 44.200* 994.900 ± 55.250ns
Serum urea (mmol/L) 6.733 ± 0.026 6.113 ± 0.733ns 3.455 ± 0.131ns 6.762 ± 0.7427ns
Urinary urea (mmol/L) 10.739 ± 0.024 11.46 ± 1.260ns 12.100 ± 0.5764ns 12.080 ± 0.8529ns
Serum total protein (g/L) 44.800 ± 0.034 43.300 ± 0.062ns 34.500 ± 0.056ns 42.300 ± 0.007ns
Urinary total protein (g/L) 7.239 ± 0.277 6.800 ± 0.036 ns 7.687 ± 0.241 ns 6.606 ± 0.434 ns
ALT (U/L) 33.350 ± 1.521 31.650 ± 2.260 ns 35.200 ± 1.218 ns 31.830 ± 1.701 ns
AST (U/L) 74.740 ± 3.420 58.220 ± 2.019* 58.270 ± 2.399* 52.100 ± 2.895*
  1. Results were expressed as Mean ± SEM for n = 5 animals per group. *:Significantly different from the control at p < 0.05
  2. ALT Alanine aminotransferase, AST Aspartate aminotransferase, ns non significative, ICR methanol extract of the roots of Imperata cylindrica