Fig. 4
From: Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1
The effects of different concentrations of indirubin on the expression of some proteins in HaCaT cells. The effects of different concentrations (0, 0.04 μ M, 0.2 μ M and 1 μ M) of indirubin on the mRNA expression of Inolucrin(a), Loricrin(b), Filaggrin(c), Keratin 17(d) and TGase1(e) in HaCaT cells. Indirubin suppresses the mRNA expression of Inolucrin, Keratin 17, TGase1, nevertheless. It barely effects on the mRNA expression of Loricrin and Filaggrin. *P < 0.05, **P < 0.01, ***P < 0.001. (N = 3)