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Fig. 6 | BMC Complementary Medicine and Therapies

Fig. 6

From: PAMs inhibits monoamine oxidase a activity and reduces glioma tumor growth, a potential adjuvant treatment for glioma

Fig. 6

PAMs alone or in combination with TMZ increased survival in intracranial glioma C57BL/6 mouse model. Mice were implanted intracranially with mouse glioma GL-26 cells and treated with vehicle, and PAMs (48 mg/kg) by daily intranasal (IN) for 14 days, or TMZ (1 mg/kg) alone by oral gavage for 10 days, and in combination with PAMs and TMZ. a PAMs alone or in combination with TMZ reduced tumor growth in intracranial glioma mouse model. Mice with glioma intracranial tumor xenografts were treated by PAMs (48 mg/kg), TMZ (1 mg/kg), PAMs (48 mg/kg) + TMZ (1 mg/kg), and vehicle. Each group n = 5. b PAMs and PAMs (48 mg/kg) + TMZ (1 mg/kg) significantly reduced the tumor weight. c PAMs and PAMs (48 mg/kg) + TMZ (1 mg/kg) increased survival compared to vehicle or TMZ group. d PAMs or PAMs (48 mg/kg) + TMZ (1 mg/kg) suppressed MAO A catalytic activity compared to vehicle. Data represent the mean ± SEM. The p-value was calculated by t-test. *p < 0.05, PAMs group compared to vehicle

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