Table 3 Antiviral (EC50) and cytotoxic (CC50) activity of Tecoma species extract and constituents
Extract/compound | MRC-5 | Vero | ZIKV | cSI | |
|---|---|---|---|---|---|
CC50 μg/mL (μM) a | CC50 μg/mL (μM) a | EC50 μg/mL (μM) b | |||
Tecoma castaneifolia | Trunk | 131.30 ± 1.39 | 102.20 ± 2.15 | 66.78 ± 3.01 | 1.53 |
Leaves | > 200.00 | > 200.00 | 61.25 ± 2.65 | > 3.27 | |
Tecoma garrocha | Trunk | > 200.00 | 159.00 ± 1.38 | 131.00 ± 1.56 | 1.21 |
Leaves | > 200.00 | > 200.00 | 149.90 ± 1.52 | > 1.33 | |
Tecoma stansvar.angustata | Trunk | 80.25 ± 1.18 | 0.4750 ± 1.28 | > 200.00 | – |
Leaves | 144.10 ± 1.33 | > 200.00 | 53.62 ± 3.25 | > 3.73 | |
Tecoma stansvar.stans | Trunk | 0.4258 ± 1.30 | 0.1934 ± 1.22 | > 200.00 | – |
Leaves | > 200.00 | > 200.00 | 98.39 ± 1.40 | > 2.03 | |
TSSDF | NT d | 86.94 ± 2.08 | > 200.00 | – | |
TSSEF | NT d | > 200.00 | 149.90 ± 3.03 | 1.33 | |
TSSAF | NT d | > 200.00 | 78.98 ± 1.54 | 2.53 | |
Crenatoside | > 100.00 (> 160.74) | 92.06 ± 1.47 (147.98 ± 1.47) | 21.64 ± 1.57 (34.78 ± 1.57) | 4.25 | |
Ribavirin | 52.66 ± 1.18 (215.65 ± 1.18) | 370.40 ± 1.20 (1516.75 ± 1.20) | 94.47 ± 2.70 (386.85 ± 2.70) | 3.92 | |