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Table 3 Antiviral (EC50) and cytotoxic (CC50) activity of Tecoma species extract and constituents

From: Anti-Zika virus activity and chemical characterization by ultra-high performance liquid chromatography (UPLC-DAD-UV-MS) of ethanol extracts in Tecoma species

Extract/compound MRC-5 Vero ZIKV cSI
CC50 μg/mL (μM) a CC50 μg/mL (μM) a EC50 μg/mL (μM) b
Tecoma castaneifolia Trunk 131.30 ± 1.39 102.20 ± 2.15 66.78 ± 3.01 1.53
Leaves >  200.00 >  200.00 61.25 ± 2.65 >  3.27
Tecoma garrocha Trunk >  200.00 159.00 ± 1.38 131.00 ± 1.56 1.21
Leaves >  200.00 >  200.00 149.90 ± 1.52 >  1.33
Tecoma stansvar.angustata Trunk 80.25 ± 1.18 0.4750 ± 1.28 >  200.00
Leaves 144.10 ± 1.33 >  200.00 53.62 ± 3.25 >  3.73
Tecoma stansvar.stans Trunk 0.4258 ± 1.30 0.1934 ± 1.22 >  200.00
Leaves >  200.00 >  200.00 98.39 ± 1.40 >  2.03
TSSDF NT d 86.94 ± 2.08 >  200.00
TSSEF NT d >  200.00 149.90 ± 3.03 1.33
TSSAF NT d >  200.00 78.98 ± 1.54 2.53
Crenatoside >  100.00
(>  160.74)
92.06 ± 1.47
(147.98 ± 1.47)
21.64 ± 1.57
(34.78 ± 1.57)
4.25
Ribavirin 52.66 ± 1.18
(215.65 ± 1.18)
370.40 ± 1.20
(1516.75 ± 1.20)
94.47 ± 2.70
(386.85 ± 2.70)
3.92
  1. a 50% cytotoxic concentration
  2. b 50% effective concentration of viral replication
  3. c SI (Selectivity index): ratio between extract/compound CC50 and EC50
  4. d NT: Not tested