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Table 5 Selectivity index of microbial strains tested against Vero and Caco2 cell lines

From: Flavonoids isolated from the South African weed Chromolaena odorata (Asteraceae) have pharmacological activity against uropathogens

Microbial strain

Cell line

Time (h)

Compound 2

Compound 3

Compound 4

 

Selectivity index (LC50/MIC)

S. aureus

Vero

–

6.516

12.313

ND

 

Caco2

–

ND

9.938

0.772

E. coli (1)

Vero

–

6.515

3.127

ND

 

Caco2

–

ND

2.52

1.544

E. coli (2)

Vero

–

6.452

0.788

ND

 

Caco2

–

ND

0.636

ND

E. coli (3)

Vero

–

6.452

0.788

ND

 

Caco2

–

ND

0.636

ND

K. pneumoniae

Vero

–

1.616

1.576

ND

 

Caco2

–

ND

1.272

NA

C. neoformans

Vero

48

12.625

NA

ND

  

72

1.616

NA

ND

 

Caco2

48

ND

NA

NA

  

72

ND

NA

NA

A. fumigatus

Vero

48

12.625

6.355

ND

  

72

1.616

0.788

ND

 

Caco2

48

ND

5.129

0.7772

  

72

ND

0.636

NA

  1. ND not detected due to LC50 greater than the highest concentration of 0.2 mg/mL tested showing no toxicity, NA not available as a result of the sample not being able to inhibit the tested fungal strain at highest concentration