Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats

Song, Jungbin; Kim, Young-Sik; Lee, Donghun; Kim, Hocheol

doi:10.1186/s12906-020-02998-1

BMC Complementary Medicine and Therapies

Table 8 Serum biochemical findings after 13-week administration of HT047

From: Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats

Parameters	units	Male dose (mg/kg/day)				Female dose (mg/kg/day)
Parameters	units	0^a	800	2000	5000	0^a	800	2000	5000
ALT	U/L	30.5 ± 5.7	31.7 ± 6.9	29.9 ± 4.6	29.2 ± 10.8	24.0 ± 6.3	25.4 ± 8.0	23.1 ± 7.9	22.2 ± 6.4
AST	U/L	77.0 ± 10.3	80.4 ± 10.7	76.7 ± 12.8	67.6 ± 12.2	68.9 ± 11.3	74.8 ± 18.0	83.9 ± 23.2	78.7 ± 20.8
ALP	U/L	279.5 ± 54.7	312.5 ± 54.2	315 ± 89.6	344.5 ± 70.7	131.3 ± 25.2	180.7 ± 37.2^*	214.6 ± 51.0^**	200.7 ± 54.2^**
Glucose	mg/dL	126 ± 14	127 ± 15	124 ± 15	124 ± 18	148 ± 7	146 ± 18	150 ± 14	132 ± 11^*
BUN	mg/dL	12.1 ± 1.4	11.5 ± 1.6	11.3 ± 1.1	10.9 ± 1.4	13.0 ± 1.9	12.9 ± 1.7	13.8 ± 2.6	14.6 ± 3.2
Creatinine	mg/dL	0.43 ± 0.05	0.43 ± 0.04	0.45 ± 0.03	0.44 ± 0.05	0.47 ± 0.05	0.44 ± 0.03	0.47 ± 0.06	0.47 ± 0.03
Total bilirubin	mg/dL	0.06 ± 0.01	0.06 ± 0.01	0.06 ± 0.03	0.06 ± 0.01	0.11 ± 0.03	0.13 ± 0.04	0.12 ± 0.03	0.13 ± 0.02
TC	mg/dL	84 ± 13	53 ± 17^##	47 ± 24^#	28 ± 5^##	87 ± 21	48 ± 24^**	46 ± 17^**	45 ± 23^**
TG	mg/dL	61 ± 19	46 ± 21	84 ± 45	87 ± 37	23 ± 7	22 ± 11	25 ± 13	29 ± 11
Total protein	g/dL	6.1 ± 0.2	5.8 ± 0.2*	6.0 ± 0.2	6.0 ± 0.2	6.2 ± 0.3	6.5 ± 0.5	6.4 ± 0.4	6.5 ± 0.6
Albumin	g/dL	2.4 ± 0.1	2.4 ± 0.1	2.4 ± 0.1	2.4 ± 0.1	2.8 ± 0.2	2.8 ± 0.3	2.7 ± 0.2	2.7 ± 0.3
A/G ratio	–	0.65 ± 0.04	0.69 ± 0.05	0.66 ± 0.05	0.65 ± 0.04	0.83 ± 0.06	0.76 ± 0.05^*	0.74 ± 0.04^**	0.71 ± 0.05^**
P	mg/dL	6.14 ± 0.59	6.01 ± 0.66	6.30 ± 0.52	6.73 ± 0.56	4.24 ± 0.41	4.97 ± 0.48	4.65 ± 0.94	4.89 ± 0.69
Ca	mg/dL	10.1 ± 0.3	9.7 ± 0.1^**	10.1 ± 0.2	10.0 ± 0.3	9.9 ± 0.2	9.9 ± 0.3	10.4 ± 1.8	9.9 ± 0.4
Na	mmol/L	141.4 ± 1.1	141.4 ± 1.2	140.9 ± 0.9	140.3 ± 0.9	140.8 ± 1.6	141.7 ± 0.6	140.0 ± 1.2	140.2 ± 0.8
K	mmol/L	4.27 ± 0.16	4.25 ± 0.27	4.29 ± 0.23	4.20 ± 0.20	4.05 ± 0.31	4.26 ± 0.16	4.14 ± 0.46	4.22 ± 0.35
Cl	mmol/L	108.0 ± 1.2	107.7 ± 1.5	106.9 ± 1.1	106.5 ± 0.9^*	108.9 ± 1.3	108.4 ± 1.3	106.2 ± 1.3^**	106.6 ± 1.9^**

^a Distilled water (10 mL/kg/day)
A/G Albumin/globulin, ALP Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate aminotransferase, BUN Blood urea nitrogen, Ca Calcium, Cl Chloride, K Potassium, Na Sodium, P Phosphorus, TC Total cholesterol, TG Triglycerides
* p < 0.05 and ** p < 0.01 vs. control by one-way ANOVA with post-hoc Dunnett’s t-test
# p < 0.05 and ## p < 0.01 vs. control by Kruskal-Wallis test with post-hoc Steel's test
Data are presented as mean ± SD (n = 10 per group)

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