Fig. 1

Assessment of the establishment of the AA model in the normal and model control groups based on the peripheral blood cell and BMNC counts (x ± SD) and bone marrow biopsies. a: Detailed experimental flow of the animal handling. b: Peripheral blood cell and BMNC counts in the different groups. c: Bone marrow biopsy of the normal group, model control group and different dose ASP groups on day 14. As indicated by the arrows,we can observe that hematopoietic tissue was replaced by adipose tissue in the AA model groups. The hematopoietic area in the treated group was appreciably larger than that in the AA group. d: The mitochondrial structure was detected by electron microscopy (× 16,500) on day 14. As indicated by the arrows, destroyed mitochondria were detected. Note: ▲P < 0.05 and ▲▲P < 0.01 compared with the normal control group. *P < 0.05 and **P < 0.01 compared with the model control group; #P < 0.05 and ##P < 0.01 compared with the low-dose group