Fig. 3

Effects of PVE on uterus volume, uterine myoma weights and uterus histology. The groups are shown as follows: control (C); model (M); GLC positive control group (GLC, 0.30 g/kg); mifepristone positive control group (MF, 5.4 mg/kg); low-dose PVE (LPVE, 0.11 g/kg); medium-dose PVE (MPVE, 0.22 g/kg); high-dose PVE (HPVE, 0.44 g/kg). Rats were treated with estradiol benzoate injection (0.4 mg) and progesterone injection (0.2 mg) every other day for 60 days for model construction. Model groups were treated with normal saline, and the other groups were treated with the indicated medicine by oral gavage for 30 days. At the end of the treatment, the uteri were collected and weighed. The uterine tissue samples were stained with HE. a uterus volume; b uterus myoma weight, compared with the control group, ^#p < 0.05, compared with the model group, *p < 0.05; c uterus histological changes by HE staining (arrow), × 400 magnification, scale bar:50 μm