Table 3 DMSCO compounds and related key targets
Compounds | Number of key targets | Targets |
|---|---|---|
Ursolic acid | 17 | MAPK8, JUN, FGF2, FOS, RELA, PTGS2, CREB1, TP53, VEGFA, IL6, STAT3, CTNNB1, MMP9, CASP3, CCND1, IL1B, MTOR |
Anethole | 7 | MAPK1, MAPK3, JUN, RELA, CDH1, AKT1, MMP9 |
Beta-sitosterol | 5 | JUN, HSP90AA1, PTGS2, CASP3, AR |
Stigmasterol | 3 | PTGS2, TNF, AR |
Tetrahydroalstonine | 3 | HSP90AA1, PTGS2, AR |
Retinol | 2 | MAPK1, JUN |
Sitosterol | 2 | CASP3, AR |
Poriferast-5-en-3beta-ol | 2 | CASP3, AR |
Hydroxygenkwanin | 2 | HSP90AA1, PTGS2 |
Safrole | 2 | PTGS2, CASP3 |
Oleanolic acid | 1 | CASP3 |
Methyleugenol | 1 | PTGS2 |
Mandenol | 1 | PTGS2 |
3,5-Dihydroxybenzoic Acid | 1 | PTGS2 |
Aristolone | 1 | PTGS2 |
Verbenalin | 1 | PTGS2 |
Elemicin | 1 | PTGS2 |
Cornudentanone | 1 | PTGS2 |
2,6,10,14,18-pentamethylicosa-2,6,10,14,18-pentaene | 1 | PTGS2 |