The risk of coronary artery disease in patients with rheumatoid arthritis using Chinese herbal products and conventional medicine in parallel: a population-based cohort study

Table 3 Hazard ratios and 95% confidence intervals of coronary artery disease risk associated with cumulative number of days of CHP use among patients with rheumatoid arthritis

	n	Event	Hazard Ratio(95% CI)		Hazard Ratio(95% CI)
	n	no.	Crude	Adjusted^†	Crude	Adjusted^†
Non-CHP group	4889	356	1(reference)	1(reference)	–	–
CHP group	4889	212	0.55 (0.46–0.65)***	0.59 (0.5–0.71)***
< 30 days	2280	99	0.58 (0.46–0.72)***	0.62 (0.50–0.78)***	1 (reference)	1 (reference)
30–180 days	1675	80	0.59 (0.47–0.76)***	0.67 (0.52–0.85)**	1.01 (0.75–1.36)	1.05 (0.78–1.41)
> 180 days	934	33	0.40 (0.28–0.58)***	0.41 (0.29–0.59)***	0.67 (0.45–1.00)	0.64 (0.43–0.95)*

Crude HR^* represented relative hazard ratio
Adjusted HR^† represented adjusted hazard ratio: mutually adjusted for age, sex, diabetes mellitus, hypertension, hyperlipidemia, COPD, ESRD, NSAID use, corticosteroid, DMARDs, and TNF-antagonists in Cox proportional hazards regression
Abbreviations: HR hazard ratio; CI confidence interval; CHP Chinese herbal products; COPD chronic obstructive pulmonary disease; ESRD end-stage renal disease
*p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 2662-7671