A mechanistic approach to HPLC analysis, antinociceptive, anti-inflammatory and postoperative analgesic activities of panch phoron in mice

Table 4 Effect of PPE in the early (0-5 min) and late phases (15-30 min) of the formalin test in mice

Treatment	Dose	Licking Time (sec)		% of inhibition
Treatment	Dose	0–5 min	15–30 min	0–5 min	15–30 min
Control (distilled water)	10 ml/kg	18 ± 1.61	6.4 ± 1.03
Na diclofenac	10 mg/kg	8.4 ± 0.51*	1.8 ± 0.37*	52.8	72.3
PPE	100 mg/kg	10.8 ± 0.86*	1.6 ± 0.24*	40.0	73.8
PPE	250 mg/kg	8.0 ± 0.32*	1.6 ± 0.24*	54.4	75.4
PPE	500 mg/kg	6.2 ± 0.37*	1.2 ± 0.20*	65.0	80.0

N = 6. Values are mean ± SEM. *p < 0.05 compared to control (Repeated measures ANOVA followed by Dunnett’s post hoc test)

ISSN: 2662-7671