Table 5 Hematological parameters
From: A 13-Week Repeated Oral Dose Toxicity Study of ChondroT in Sprague-Dawley Rats
Parameters | Group(Dose)* | G1(0) | G2(500) | G3(1000) | G4(2000) | ||
|---|---|---|---|---|---|---|---|
Sex/Week | 13week | 17week#,** | 13week | 13week## | 13week** | 17week# | |
Total leucocyte count (103cells/μL) | Male | 5.09±1.38 | 6.55±2.37 | 5.39±1.13 | 6.15±2.13 | 6.27±3.02 | 5.86±1.39 |
Female | 3.18±0.56 | 3.00±1.07 | 2.66±0.80 | 5.10±5.41 | 4.16±0.66 | 2.89±1.08 | |
Total erythrocyte count (106cells/μL) | Male | 8.44±0.33 | 7.97±0.48 | 8.38±0.21 | 8.16±0.79 | 8.16±0.94 | 8.17±0.35 |
Female | 7.78±0.35 | 7.24±0.10 | 7.53±0.34 | 7.55±0.45 | 7.45±0.24 | 7.30±0.15 | |
Hemoglobin concentration (g/dL) | Male | 14.6±0.7 | 14.0±0.7 | 14.4±0.4 | 14.5±1.2 | 14.2±1.4 | 14.3±0.4 |
Female | 14.2±0.6 | 13.5±0.3 | 13.8±0.6 | 13.8±0.8 | 13.7±0.4 | 13.8±0.3 | |
Hematocrit(%) | Male | 42.2±1.7 | 40.1±2.0 | 42.1±1.0 | 42.0±4.1 | 41.0±4.1 | 41.0±1.1 |
Female | 41.1±1.7 | 38.6±0.5 | 40.0±1.6 | 40.1±1.9 | 39.5±0.9 | 39.4±0.9 | |
Mean corpuscular volume (fL) | Male | 50.0±1.5 | 50.3±0.9 | 50.3±1.6 | 51.5±1.3 | 50.4±1.4 | 50.3±1.5 |
Female | 52.9±1.4 | 53.3±0.5 | 53.2±1.5 | 53.1±1.4 | 53.2±2.0 | 54.1±1.0 | |
Mean corpuscular hemoglobin (pg) | Male | 17.2±0.6 | 17.6±0.3 | 17.2±0.6 | 17.8±0.5 | 17.4±0.6 | 17.5±0.6 |
Female | 18.3±0.4 | 18.7±0.4 | 18.4±0.7 | 18.2±0.5 | 18.4±0.7 | 18.9±0.1 | |
Mean corpuscular hemoglobin concentration(g/dL) | Male | 34.5±0.5 | 35.0±0.5 | 34.2±0.4 | 34.5±0.6 | 34.6±0.5 | 34.9±0.4 |
Female | 34.6±0.3 | 35.1±0.7 | 34.6±0.6 | 34.4±0.4 | 34.6±0.4 | 35.0±0.5 | |
Reticulocyte(109cells/μL) | Male | 155.3±45.7 | 169.5±60.4 | 164.2±34.1 | 160.0±32.8 | 200.1±95.6 | 184.8±19.0 |
Female | 150.4±40.2 | 172.6±34.6 | 142.1±29.5 | 176.4±72.4 | 179.2±31.4 | 146.6±26.4 | |
Reticulocyte(%) | Male | 1.84±0.53 | 2.14±0.83 | 1.96±0.32 | 1.95±0.32 | 2.43±1.03 | 2.26±0.21 |
Female | 1.94±0.51 | 2.39±0.51 | 1.89±0.37 | 2.37±1.10 | 2.41±0.45 | 2.01±0.34 | |
Platelet(103cells/μL) | Male | 1041.3±142.1 | 830.0±431.1 | 973.9±73.6 | 849.6±306.5 | 819.6±452.8 | 1035.6±70.1 |
Female | 967.6±68.5 | 741.6±402.8 | 844.3±300.9 | 1008.5±99.2 | 969.0±85.8 | 1006.8±99.1 | |
Prothrombin time(sec) | Male | 13.6±0.8 | 13.1±0.4 | 14.5±1.1 | 14.9±1.6 | 14.0±1.9 | 12.7±0.4 |
Female | 12.6±0.4 | 13.4±1.9 | 12.4±0.3 | 12.4±0.4 | 12.3±0.3 | 12.9±0.2 | |
Activated partial thromboplastin time(sec) | Male | 17.7±1.7 | 17.7±2.6 | 20.1±1.7 | 19.4±1.9 | 19.0±3.2 | 15.9±2.8 |
Female | 14.6±1.4 | 14.8±3.6 | 14.8±1.2 | 14.4±1.5 | 14.1±1.6 | 16.5±2.0 | |
Neutrophils(%) | Male | 21.2±10.0 | 16.2±6.9 | 20.4±6.4 | 18.9±6.4 | 17.9±4.4 | 17.8±3.2 |
Female | 19.9±7.6 | 16.4±2.8 | 15.7±4.8 | 26.4±16.7 | 15.3±4.3 | 22.3±3.1†| |
Lymphocytes(%) | Male | 73.1±11.3 | 78.2±7.8 | 73.1±7.3 | 76.3±7.5 | 76.9±5.0 | 75.7±4.2 |
Female | 73.0±7.7 | 76.5±3.3 | 78.3±5.3 | 67.1±15.9 | 79.2±5.1 | 68.5±4.9†| |
Monocytes(%) | Male | 2.2±1.0 | 1.6±0.2 | 2.4±0.5 | 1.8±0.7 | 2.2±1.1 | 2.1±0.4†|
Female | 2.4±0.3 | 2.1±0.7 | 1.7±0.8 | 2.1±0.5 | 1.8±0.5 | 1.9±0.5 | |
Eosinophils(%) | Male | 1.9±0.8 | 2.8±1.2 | 2.0±1.0 | 1.5±0.7 | 1.6±0.4 | 3.5±0.7 |
Female | 3.0±1.0 | 4.0±1.7 | 3.0±1.6 | 3.3±1.6 | 2.3±0.6 | 6.6±3.1 | |
Basophils(%) | Male | 0.1±0.1 | 0.2±0.1 | 0.2±0.1 | 0.2±0.1 | 0.2±0.0 | 0.1±0.1 |
Female | 0.1±0.1 | 0.1±0.3 | 0.1±0.1 | 0.1±0.1 | 0.1±0.1 | 0.1±0.0†| |