Fig. 6

Target network of bradycardia. (A) Disease related genes are displayed by a classification of location in body. Differenttypes are represented by different shapes. Most of the targets exist in the cell membrane, mainly ion channels and G protein-coupled receptors. (B) In the overview of adrenergic signaling pathway in cardiomyocytes, the ADR family is at a relatively upstream position (colored in red). Other identified targets by SXSM components are colored in pink or yellow