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Table 3 Percent AChE and BChE inhibition potentials of Bergenia ciliata Rhizome Crude extract and their sub fractions

From: Isolation of bioactive compounds from Bergenia ciliata (haw.) Sternb rhizome and their antioxidant and anticholinesterase activities

Sample Concentration (μg/ml) Percent AChE (mean ± SEM) AChE IC50 (μg/ml) Percent BChE (mean ± SEM) BChE IC50 (μg/ml)
Crude 1000 90.22 ± 1.15 ns   88.22 ± 0.71**  
500 80.15 ± 0.70** 72 80.47 ± 0.86 ns 85
250 71.28 ± 0.73 ns   67.90 ± 3.30***  
125 57.26 ± 0.42**   56.75 ± 2.25 ns  
n-Butanol 1000 82.33 ± 1.07***   80.43 ± 1.15***  
500 70.23 ± 3.31*** 140 71.80 ± 0.90***  
250 58.67 ± 1.20***   61.20 ± 0.65*** 150
125 49.93 ± 0.75***   48.83 ± 2.33***  
Ethyl acetate 1000 75.32 ± 2.45***   73.26 ± 0.60***  
500 66.34 ± 0.60***   60.31 ± 0.81***  
250 53.66 ± 1.17*** 185 50.33 ± 2.33*** 215
125 44.76 ± 0.73***   35.85 ± 0.68***  
Chloroform 1000 66.69 ± 0.45***   69.19 ± 0.72***  
500 57.39 ± 3.26***   60.66 ± 0.94***  
250 46.19 ± 1.08*** 311 45.75 ± 0.42*** 350
125 36.80 ± 0.73***   34.69 ± 0.49***  
Aqueous 1000 60.45 ± 2.33***   65.37 ± 0.50***  
500 55.63 ± 1.40***   51.27 ± 0.81***  
250 43.11 ± 0.78*** 400 37.63 ± 0.46*** 470
125 31.66 ± 0.76***   24.31 ± 2.42***  
n-Hexane 1000 50.54 ± 1.33***   60.66 ± 0.60***  
500 45.80 ± 2.26*** 650 47.56 ± 0.60***  
250 30.38 ± 0.47***   33.46 ± 0.88*** 560
125 18.66 ± 2.30***   20.38 ± 0.68***  
Galanthamine 1000 95.32 ± 0.88   94.50 ± 0.71  
500 87.74 ± 0.55 45 84.66 ± 1.20 60
250 76.44 ± 0.60   76.72 ± 0.72  
125 64.58 ± 0.54   60.83 ± 0.69  
  1. Galanthamine was used as a positive control. Data is represented as (mean ± S.E.M) n = 3. Values significantly different as compared to positive control, *: P < 0.05, **: P < 0.01, ***: P < 0.001, ns: P > 0.05