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Table 3 The distribution and mean scores of histopathological changes due to toxicity in mice kidney of each group

From: Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin

Features/ Groups Inflammation Degeneration Necrosis Bowman capsule dilatation Glomeruli cellularity
Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M Distribution (n = 10) Mean score ± S.E.M
I (vehicle control) 8 0.8 ± 0.1 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 0 0.0 ± 0.0
II (carcinogen control) 10 2.3 ± 0.2a 2 0.2 ± 0.1a 0 0.0 ± 0.0a 6 0.6 ± 0.2a 8 1.0 ± 0.2a
III (treatment, annonacin) 9 0.9 ± 0.1 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 0 0.0 ± 0.0
IV (treatment control) 6 0.5 ± 0.2 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 0 0.0 ± 0.0
V (reference, curcumin) 10 1.2 ± 0.1 0 0.0 ± 0.0 0 0.0 ± 0.0a 0 0.0 ± 0.0 0 0.0 ± 0.0
  1. Values expressed as mean ± S.E.M (n = 10). Means between groups that have no superscript in common are significantly different (Tukey’s LSD, p < 0.05)