Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying

Illuri, Ramanaiah; Venkataramana, Sudeep Heggar; Daguet, David; Kodimule, Shyamprasad

doi:10.1186/s12906-019-2576-7

BMC Complementary Medicine and Therapies

Table 4 Effect of Asdamarin on haematological parameters in rats

From: Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying

	Unit	Control	Asdamarin (mg/kg, B.W)
	Unit	Control	250	500	1000	1000 Reversal
Male
Haemoglobin	g/dL	16.78 ± 0.56	17.60 ± 0.27	15.40 ± 0.66	16.06 ± 0.56	16.26 ± 0.51
RBC	10⁶/μL	9.848 ± 1.25	8.55 ± 0.15	7.72 ± 0.24	7.97 ± 0.3	7.97 ± 0.27
HCT	%	43.98 ± 0.66	45.66 ± 0.53	40.40 ± 1.08	41.24 ± 1.84	41.00 ± 1.26
MCV	fL	51.98 ± 1.03	53.54 ± 1.16	52.48 ± 1.33	51.80 ± 0.85	51.52 ± 0.82
MCH	Pg	19.74 ± 0.39	20.56 ± 0.41	19.86 ± 0.3	20.12 ± 0.20	20.34 ± 0.32
MCHC	g/dL	38.10 ± 1.06	38.50 ± 0.22	38.04 ± 1.06	38.96 ± 0.43	39.60 ± 0.35
Platelets	10³/μL	270.6 ± 21.78	307.4 ± 16.85	313.0 ± 16.88	313.6 ± 10.16	311.4 ± 20.48
WBC	10³/μL	22.06 ± 0.87	19.22 ± 3.12	19.46 ± 1.29	19.62 ± 2.76	20.04 ± 2.11
Lymphocytes	%	90.92 ± 1.66	88.74 ± 0.88	93.84 ± 0.62	93.94 ± 0.76	90.20 ± 1.47
Monocytes	%	3.18 ± 0.41	3.42 ± 0.19	2.35 ± 0.16	2.27 ± 0.14	2.97 ± 0.30
Neutrophils	%	4.54 ± 1.08	6.38 ± 0.7	2.80 ± 0.41	2.82 ± 0.56	5.56 ± 1.08
Eosinophils	%	1.33 ± 0.17	1.43 ± 0.07	0.99 ± 0.07	0.95 ± 0.06	1.25 ± 0.12
Basophils	%	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.02
Clotting time	Seconds	33.0 ± 14.59	32.60 ± 4.49	39.80 ± 21.67	25.00 ± 4.50	27.40 ± 5.97
Female
Haemoglobin	g/dL	16.68 ± 0.57	15.48 ± 0.30	16.64 ± 0.466	15.50 ± 0.59	15.42 ± 0.34
RBC	10⁶/μL	7.57 ± 0.26	7.67 ± 0.21	7.13 ± 0.24	6.93 ± 0.62	7.45 ± 0.10
HCT	%	43.98 ± 1.66	39.22 ± 0.53	38.78 ± 1.03	36.84 ± 3.15	39.36 ± 0.72
MCV	fL	58.14 ± 1.22	54.28 ± 1.18	56.74 ± 0.83	60.32 ± 1.09	56.90 ± 0.33
MCH	Pg	22.00 ± 0.29	20.16 ± 0.39	20.48 ± 0.31	21.38 ± 1.59	20.64 ± 0.27
MCHC	g/dL	37.90 ± 0.36	39.42 ± 0.26	39.74 ± 0.31	40.18 ± 2.81	39.14 ± 0.35
Platelets	10³/μL	310.8 ± 40.08	345.2 ± 12.87	300.0 ± 28.68	338.8 ± 41.25	272.8 ± 18.13
WBC	10³/μL	11.02 ± 1.71	8.28 ± 1.25	8.40 ± 1.38	9.36 ± 1.53	9.36 ± 1.58
Lymphocytes	%	91.28 ± 1.66	94.30 ± 0.24	94.64 ± 0.79	93.04 ± 0.58	92.18 ± 1.82
Monocytes	%	2.954 ± 0.52	2.18 ± 0.11	2.19 ± 0.34	2.016 ± 0.24	2.70 ± 0.52
Neutrophils	%	4.50 ± 0.97	2.58 ± 0.12	3.22 ± 0.33	3.08 ± 0.28	3.96 ± 1.21
Eosinophils	%	1.25 ± 0.22	0.92 ± 0.04	0.92 ± 0.15	0.85 ± 0.10	1.13 ± 0.21
Basophils	%	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.02	0.06 ± 0.02
Clotting time	Seconds	64.2 ± 19.90	33.0 ± 5.46	26.40 ± 3.09	39.00 ± 11.79	53.80 ± 14.61

Values are expressed as mean ± s.e.m. (n = 10 for each group). *p < 0.05 were considered significant using one-way Anova

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