Sub-acute and acute toxicity of Ferula asafoetida and Silybum marianum formulation and effect of the formulation on delaying gastric emptying

Table 3 Relative organ weights of rats treated with Asdamarin for 28 days

Sex	Organ	Control	Asdamarin (mg/kg, B.W)
Sex	Organ	Control	250 mg/kg	500 mg/kg	1000 mg/kg	1000 R mg/kg
Male	Brain	0.808 ± 0.05	0.795 ± 0.03	0.659 ± 0.006*	0.714 ± 0.042	0.686 ± 0.014
	Heart	0.368 ± 0.03	0.337 ± 0.01	0.308 ± 0.006	0.326 ± 0.016	0.303 ± 0.004
	Liver	3.613 ± 0.14	3.360 ± 0.13	3.511 ± 0.126	3.815 ± 0.126	2.456 ± 0.047
	Spleen	0.486 ± 0.09	0.44 ± 0.02	0.399 ± 0.036	0.447 ± 0.04	0.392 ± 0.03
	Kidneys	0.339 ± 0.01	0.335 ± 0.02	0.308 ± 0.019	0.341 ± 0.015	0.284 ± 0.009
Female	Brain	0.930 ± 0.033	0.858 ± 0.022	0.914 ± 0.028	0.913 ± 0.019	0.874 ± 0.032
	Heart	0.403 ± 0.026	0.388 ± 0.021	0.385 ± 0.0187	0.396 ± 0.007	0.336 ± 0.013
	Liver	3.349 ± 0.331	3.199 ± 0.150	3.054 ± 0.228	3.150 ± 0.089	2.627 ± 0.084
	Spleen	0.520 ± 0.061	0.465 ± 0.076	0.448 ± 0.036	0.523 ± 0.045	0.325 ± 0.026
	Kidneys	0.503 ± 0.025	0.515 ± 0.015	0.505 ± 0.022	0.521 ± 0.008	0.455 ± 0.024

Values are expressed as mean ± s.e.m. (n = 10 for each group). *p < 0.05 were considered significant using one-way Anova. * denote significant difference compared to control

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