Table 3 The 62 major targets information of P-P network
ID | Major target | Uniprot ID | Gene name |
|---|---|---|---|
MT1 | Interleukin-6 | P05231 | IL6 |
MT2 | Epidermal growth factor receptor | P00533 | EGFR |
MT3 | Transcription factor AP-1 | P05412 | JUN |
MT4 | Apoptosis regulator Bcl-2 | P10415 | BCL2 |
MT5 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 |
MT6 | Serine-protein kinase ATM | Q13315 | ATM |
MT7 | Tyrosine-protein kinase JAK2 | O60674 | JAK2 |
MT8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | O00329 | PIK3CD |
MT9 | Receptor tyrosine-protein kinase erbB-2 | P04626 | ERBB2 |
MT10 | Baculoviral IAP repeat-containing protein 5 | O15392 | BIRC5 |
MT11 | Interleukin-1 beta | P01584 | IL1B |
MT12 | Receptor-type tyrosine-protein phosphatase C | P08575 | PTPRC |
MT13 | Mitogen-activated protein kinase 11 | Q15759 | MAPK11 |
MT14 | Interleukin-10 | P22301 | IL10 |
MT15 | C-X-C chemokine receptor type 4 | P61073 | CXCR4 |
MT16 | Amyloid-beta A4 protein | P05067 | APP |
MT17 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | O15111 | CHUK |
MT18 | POU domain, class 5, transcription factor 1 | Q01860 | POU5F1 |
MT19 | Cyclin-dependent-like kinase 5 | Q00535 | CDK5 |
MT20 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | ABCG2 |
MT21 | Cation-independent mannose-6-phosphate receptor | P11717 | IGF2R |
MT22 | Cyclin-dependent kinase inhibitor 1B | P46527 | CDKN1B |
MT23 | ALK tyrosine kinase receptor | Q9UM73 | ALK |
MT24 | E3 ubiquitin-protein ligase CBL | P22681 | CBL |
MT25 | Substance-P receptor | P25103 | TACR1 |
MT26 | Wilms tumor protein | P19544 | WT1 |
MT27 | ETS-related transcription factor Elf-3 | P78545 | ELF3 |
MT28 | G1/S-specific cyclin-D2 | P30279 | CCND2 |
MT29 | Amine oxidase [flavin-containing] A | P21397 | MAOA |
MT30 | Metalloproteinase inhibitor 1 | P20414 | TIMP1 |
MT31 | Kinesin-like protein KIF11 | P52732 | KIF11 |
MT32 | Cell division cycle protein 16 homolog | Q13042 | CDC16 |
MT33 | Nitric oxide synthase, brain | P29475 | NOS1 |
MT34 | DNA (cytosine-5)-methyltransferase 3B | Q9UBC3 | DNMT3B |
MT35 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | P19174 | PLCG1 |
MT36 | POU domain class 2-associating factor 1 | Q16633 | POU2AF1 |
MT37 | E3 ubiquitin-protein ligase XIAP | P98170 | XIAP |
MT38 | Anaphase-promoting complex subunit 10 | Q9UM13 | ANAPC10 |
MT39 | Runt-related transcription factor 1 | Q01196 | RUNX1 |
MT40 | WD repeat and FYVE domain-containing protein 2 | Q96P53 | WDFY2 |
MT41 | M-phase inducer phosphatase 1 | P30304 | CDC25A |
MT42 | D(2) dopamine receptor | P14416 | DRD2 |
MT43 | CASP8 and FADD-like apoptosis regulator | O15519 | CASP8 |
MT44 | Cyclin-dependent kinase 3 | Q00526 | CDK3 |
MT45 | Tyrosine-protein phosphatase non-receptor type 2 | P17706 | PTPN2 |
MT46 | DNA mismatch repair protein Mlh1 | P40692 | MLH1 |
MT47 | Wee1-like protein kinase | P30291 | WEE1 |
MT48 | Neural cell adhesion molecule 1 | P30291 | NCAM1 |
MT49 | Caspase-9 | P55211 | CASP9 |
MT50 | Toll-like receptor 3 | O15455 | TLR3 |
MT51 | C-X-C motif chemokine 2 | P19875 | CXCL2 |
MT52 | 5-hydroxytryptamine receptor 1A | P08908 | HTR1A |
MT53 | Mothers against decapentaplegic homolog 7 | O15105 | SMAD7 |
MT54 | Transcription factor 4 | P15884 | TCF4 |
MT55 | Tyrosine-protein kinase JAK3 | P52333 | JAK3 |
MT56 | Interleukin-2 receptor subunit alpha | P01589 | IL2RA |
MT57 | Non-receptor tyrosine-protein kinase TYK2 | P29597 | TYK2 |
MT58 | Dual specificity protein phosphatase CDC14A | Q9UNH5 | CDC14A |
MT59 | Cyclin-dependent kinase 9 | P50750 | CDK9 |
MT60 | Presenilin-1 | P49768 | PSEN1 |
MT61 | Apolipoprotein B-100 | P04114 | APOB |
MT62 | C-X-C motif chemokine 13 | O43927 | CXCL13 |