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Table 4 Effect of oral administration of OE on serum biochemical profiles

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Tests Male Female
G1 G2 G3 G4 G1 G2 G3 G4
AST (U/L) 118.1 ± 15.9 110.0 ± 15.5 102.6 ± 13.2 114.3 ± 10.4 80.5 ± 11.0 81.3 ± 3.4 84.3 ± 14.7 85.9 ± 11.4
ALT (U/L) 27.0 ± 3.9 32.9 ± 7.5 27.4 ± 4.4 29.5 ± 4.2 21.6 ± 2.6 22.3 ± 3.2 18.0 ± 1.0 34.1 ± 2.4**
ALP (U/L) 190.4 ± 5.3 213.1 ± 39.1 192.3 ± 3.5 210.2 ± 42.6 135.0 ± 41.5 121.7 ± 13.3 126.8 ± 23.6 145.6 ± 27.3
CPK (U/L) 763.0 ± 156.9 578.3 ± 113.2 525.0 ± 16.6 628.3 ± 227.0 216.0 ± 14.7 232.0 ± 63.0 262.3 ± 217.2 181.0 ± 68.1
TBIL (mg/dL) 0.11 ± 0.02 0.11 ± 0.01 0.12 ± 0.02 0.11 ± 0.02 0.11 ± 0.01 0.11 ± 0.02 0.10 ± 0.02 0.14 ± 0.01*
GLU (mg/dL) 97.6 ± 5.4 110.7 ± 13.2 122.4 ± 27.7 108.1 ± 29.4 117.1 ± 6.4 122.0 ± 5.2 120.2 ± 3.5 110.2 ± 11.4
TCHO (mg/dL) 84.0 ± 10.4 75.7 ± 3.2 82.7 ± 3.8 79.3 ± 13.7 72.7 ± 9.0 75.7 ± 7.6 72.7 ± 8.3 77.3 ± 10.1
TG (mg/dL) 99.3 ± 7.6 74.7 ± 13.8 95.3 ± 25.7 88.3 ± 17.2 37.3 ± 5.0 28.0 ± 4.0 25.7 ± 5.0* 42.7 ± 6.0
TP (g/dL) 5.44 ± 0.19 5.40 ± 0.26 5.50 ± 0.14 5.44 ± 0.29 5.53 ± 0.10 5.42 ± 0.19 5.49 ± 0.25 5.33 ± 0.19
Albumin (g/dL) 2.92 ± 0.10 2.89 ± 0.09 2.93 ± 0.09 2.89 ± 0.13 3.05 ± 0.05 3.02 ± 0.12 3.04 ± 0.11 2.97 ± 0.14
A/G ratio 1.16 ± 0.02 1.16 ± 0.05 1.14 ± 0.06 1.14 ± 0.04 1.23 ± 0.05 1.26 ± 0.03 1.25 ± 0.06 1.26 ± 0.07
BUN (mg/dL) 9.6 ± 0.9 13.2 ± 0.8** 14.9 ± 1.5** 13.0 ± 1.4** 15.6 ± 2.3 14.2 ± 1.6 15.8 ± 3.1 13.7 ± 0.9
CRE (mg/dL) 0.37 ± 0.01 0.40 ± 0.05 0.36 ± 0.03 0.36 ± 0.03 0.42 ± 0.08 0.39 ± 0.02 0.37 ± 0.01 0.37 ± 0.04
IP (mg/dL) 8.95 ± 0.29 8.96 ± 0.31 8.79 ± 0.21 8.52 ± 0.22 7.88 ± 0.19 7.88 ± 0.41 7.52 ± 0.48 7.49 ± 0.51
Ca2+ (mmol/L) 9.80 ± 0.13 9.76 ± 0.11 9.87 ± 0.20 9.65 ± 0.30 9.85 ± 0.15 9.86 ± 0.12 9.90 ± 0.12 9.91 ± 0.07
Na+ (mmol/L) 141.8 ± 2.8 143.0 ± 0.8 141.9 ± 0.9 141.5 ± 0.6 140.2 ± 0.8 140.5 ± 1.3 141.5 ± 0.4 140.7 ± 0.5
K+ (mmol/L) 5.05 ± 0.57 4.91 ± 0.37 4.99 ± 0.17 4.87 ± 0.56 4.84 ± 0.34 4.84 ± 0.13 4.62 ± 0.08 4.41 ± 0.14
Cl (mmol/L) 98.9 ± 2.8 101.0 ± 2.0 99.8 ± 0.9 99.9 ± 1.0 103.5 ± 1.1 103.7 ± 1.5 103.9 ± 1.3 102.6 ± 1.2
  1. G1: negative control; G2: 500 mg/kg OE treated group; G3: 1000 mg/kg OE treated group; G4: 2000 mg/kg OE treated group
  2. AST: aspartate aminotransferase, ALT: alanine aminotransferase, ALP: alkaline phosphatase, CPK: creatinine phosphokinase, TBIL: Total bilirubin, GLU: glucose, TCHO: total cholesterol, TG: triglyceride, TP: total protein, ALB: albumin, A/G: Albumin/Globulin, BUN: blood urea nitrogen, CRE: creatinine, IP: inorganic phosphorus
  3. Data are expressed as mean ± SD. **Significant difference at P < 0.01 levels compared with the vehicle control. Bonferroni’s post hoc test was used following a one-way ANOVA vs. G1, and the homogeneity of variance was tested using Levene’s test