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Fig. 6 | BMC Complementary and Alternative Medicine

Fig. 6

From: Absence of herb-drug interactions of mistletoe with the tamoxifen metabolite (E/Z)-endoxifen and cytochrome P450 3A4/5 and 2D6 in vitro

Fig. 6

In vitro effects of mistletoe preparations (VAEP, VAEQu and VAEM) on (a) CYP2D6 and (b) CYP3A4/5 catalyzed metabolism of tamoxifen. Results are presented as mean rate values ± SE (from three independent experiments) of (E/Z)-endoxifen formation in vitro expressed as a percent of the control without inhibitor. Significance values are given relative to the negative controls without inhibitors (*p < 0.05, **p < 0.01, ***p < 0.001)

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