Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

Yun, Jun-Won; Kwon, Euna; Kim, Yun-Soon; Kim, Seung-Hyun; You, Ji-Ran; Kim, Hyoung-Chin; Park, Jin-Sung; Che, Jeong-Hwan; Lee, Sang-Koo; Jang, Ja-June; Kim, Hyeon Hoe; Kang, Byeong-Cheol

doi:10.1186/s12906-018-2315-5

BMC Complementary Medicine and Therapies

Table 3 Organ weights of male and female F344 rats orally administered with Tiglium seed extract for 13 weeks

From: Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

		Dose of Tiglium seed (mg/kg)
		0^a	31.25	62.5	125	250	500
Males
Liver	(g)	10.564 ± 0.488	10.654 ± 0.516	10.171 ± 0.727	10.782 ± 0.883	10.378 ± 0.862	9.816 ± 0.560
Liver	(%BW)	3.188 ± 0.109	3.303 ± 0.162	3.195 ± 0.144	3.331 ± 0.204	3.301 ± 0.226	3.216 ± 0.179
Kidney	(g)	0.991 ± 0.023	0.981 ± 0.044	0.957 ± 0.063	0.987 ± 0.066	0.965 ± 0.087	0.934 ± 0.049
Kidney	(%BW)	0.300 ± 0.015	0.304 ± 0.017	0.301 ± 0.016	0.305 ± 0.012	0.307 ± 0.015	0.306 ± 0.012
Testis	(g)	1.408 ± 0.050	1.420 ± 0.066	1.396 ± 0.066	1.439 ± 0.075	1.426 ± 0.060	1.439 ± 0.119
Testis	(%BW)	0.426 ± 0.023	0.440 ± 0.015	0.439 ± 0.023	0.445 ± 0.024	0.454 ± 0.024	0.471 ± 0.036*
Thymus	(g)	0.228 ± 0.011	0.231 ± 0.025	0.209 ± 0.027	0.206 ± 0.013	0.198 ± 0.017*	0.190 ± 0.024*
Thymus	(%BW)	0.069 ± 0.005	0.071 ± 0.005	0.066 ± 0.010	0.064 ± 0.004	0.063 ± 0.003	0.062 ± 0.008
Heart	(g)	0.937 ± 0.058	0.915 ± 0.039	0.933 ± 0.063	0.922 ± 0.049	0.910 ± 0.051	0.902 ± 0.047
Heart	(%BW)	0.282 ± 0.010	0.283 ± 0.008	0.293 ± 0.009	0.285 ± 0.010	0.289 ± 0.007	0.295 ± 0.009*
Lung	(g)	1.234 ± 0.050	1.171 ± 0.069	1.181 ± 0.063	1.216 ± 0.125	1.181 ± 0.100	1.197 ± 0.071
Lung	(%BW)	0.373 ± 0.016	0.363 ± 0.019	0.371 ± 0.016	0.377 ± 0.051	0.376 ± 0.022	0.392 ± 0.026
Females
Liver	(g)	5.176 ± 0.348	5.293 ± 0.150	5.257 ± 0.249	5.212 ± 0.189	5.126 ± 0.350	5.152 ± 0.204
Liver	(%BW)	2.844 ± 0.193	2.872 ± 0.090	2.917 ± 0.192	2.887 ± 0.160	2.849 ± 0.168	2.885 ± 0.106
Kidney	(g)	0.578 ± 0.039	0.580 ± 0.027	0.586 ± 0.026	0.577 ± 0.030	0.581 ± 0.034	0.586 ± 0.022
Kidney	(%BW)	0.317 ± 0.019	0.315 ± 0.016	0.324 ± 0.009	0.319 ± 0.012	0.323 ± 0.016	0.328 ± 0.010
Thymus	(g)	0.191 ± 0.008	0.192 ± 0.014	0.189 ± 0.014	0.193 ± 0.024	0.184 ± 0.024	0.185 ± 0.016
Thymus	(%BW)	0.105 ± 0.004	0.104 ± 0.006	0.105 ± 0.007	0.107 ± 0.015	0.102 ± 0.012	0.103 ± 0.009
Heart	(g)	0.579 ± 0.026	0.578 ± 0.024	0.575 ± 0.029	0.567 ± 0.044	0.562 ± 0.030	0.574 ± 0.021
Heart	(%BW)	0.318 ± 0.015	0.314 ± 0.008	0.318 ± 0.010	0.313 ± 0.014	0.312 ± 0.011	0.321 ± 0.008
Lung	(g)	0.923 ± 0.112	0.822 ± 0.061	0.851 ± 0.055	0.868 ± 0.081	0.854 ± 0.036	0.855 ± 0.051
Lung	(%BW)	0.507 ± 0.066	0.446 ± 0.031	0.471 ± 0.027	0.481 ± 0.055	0.475 ± 0.019	0.479 ± 0.037

Data expressed as means ± SD
*Significantly different from Control group (p < 0.05)
^aControl group

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