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Table 4 Cytotoxic effects of the tested fractions

From: Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation

  IC50 a (μg/mL)
Fractions MCF-7 MDA MB 231 A2780 A2780 CP HepG2 HCT-116
Hexane fraction 19.7 0.76 7.15 20.27 55.4 25
Ethyl acetate fraction 17.5 0.35 2.82 19.2 28.5 14.2
n-Butanol fraction 218.4 43 94.01 273 358.5 169.5
Water fraction > 1000 > 1000 > 1000 > 1000 > 1000 > 1000
Fraction I 3.5 0.15 4.9 5.9 0.27 0.15
Fraction III 6.80 0.12 20.5 17.5 0.52 0.65
  1. Inhibitory effects of the fractions from the extract of Cucumis prophetarum var. prophetarum fruits on the proliferation of MCF7, MDA-MB-231, HCT-116, A2780, A2780CP, and HepG2. Cell were treated with 0–1000 μg/ml. a IC50: is the concentration that inhibited cell proliferation by 50%. n = 8
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