Fig. 1

Alternative splicing of Bcl-x and Caspase 9. a Chemical structure of HHT. b Schematic splicing of Bcl-x pre-mRNA generating Bcl-xL and Bcl-xS mRNA via alternative 5′ splice site selection. c Schematic splicing of Caspase 9 pre-mRNA generating Caspase 9a and Caspase 9b mRNA via cassette exon (3, 4, 5, 6) inclusion and exclusion, respectively